Naslov
The effect of higher BMI on risk for asthma and treatment outcome in overweight and obese children

Autori
Banic, Ivana ; Bulat Lokas, Sandra ; Zivkovic, Jelena ; Nogalo, Boro ; Mrkic Kobal, Iva ; Plavec, Davor ; Turkalj, Mirjana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
Pediatric Allergy and Asthma Meeting

Mjesto i datum
Berlin, Njemačka, 15.10.2015. - 17.10.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Obesity, children, asthma

Sažetak
Introduction: Asthma and obesity have a considerable impact on public health with obesity being a risk factor for asthma. Obesity can reduce pulmonary compliance, lung volumes and the ventilation-perfusion relationship. Aims and Objectives: To assess the effect of higher BMI on risk for asthma, airway inflammation and treatment outcomes in asthmatic children. Methods: Of 2000 children (healthy and asthmatics), a cohort of 475 children with asthma was recruited. They underwent physical examination, basic anthropometric measurements, blood sampling and lung function tests. We clinically assessed their health status and treatment outcome at the point of diagnosis, after 6 months and after 12 months. Results: Participants were categorized into 4 groups according to BMI percentile: underweight, normal, overweight and obese. Increased body weight was more prevalent in male participants, both overweight and obese, than in female. Baseline levels of hsCRP were elevated both in overweight and obese participants, compared to children with normal BMI. When treatment success was assessed by changes in airway inflammation after 6 months, increased FeNO levels were more frequent in inadequate and bad responders, compared to children with good response to treatment. The risk for asthma in all 2000 children was higher in overweight participants compared to children with normal BMI, but not in obese. Conclusions: The effect of obesity appears to be insufficient in the development of asthma alone. Increased BMI (overweight) increases the risk for asthma and obesity rather increases the level of airway and systemic inflammation and potentially affects the level of disease control and response to asthma treatment.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA