Naslov
Apolipoprotein E genotypes in relation with Hg, MeHg, As and Se levels in mothers and their newborns

Autori
Trdin, Ajda ; Falnoga, Ingrid ; Snoj Tratnik, Janja ; Mazej, Darja ; Stajnko, Anja ; Marc, Janja ; Krsnik, Mladen ; Osredkar, Joško ; Prpić, Igor ; Špirić, Zdravko ; Horvat, Milena

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
ICMGP 2017 Abstract Volume / Driscoll, Charles ; Chen, Celia - Providence (RI) : ICMGP2017, 2017, 231-231

Skup
The 13Th InTernaTIonal ConferenCe on MerCury as a Global PolluTanT

Mjesto i datum
Providence (RI), Sjedinjene Američke Države, 16.07.2017. - 21.07.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Apolipoprotein E, genotypes, Hg, MeHg, As and Se levels, mothers and their newborns

Sažetak
INTRODUCTION: Apolipoprotein E (ApoE, gene APOE) is a lipid binding plasma glycoprotein with central roles in lipid metabolism and neurobiology. Some studies point on its antioxidative, metal-binding and immunomodulatory/anti-inflammatory properties. It has three major isoforms (ApoE2, ApoE3 and ApoE4) encoded by alleles ε2, ε3 and ε4. A large number of studies estimated, that isoform ε4 allele can be associated with different age related disadvantages. Individuals with ε4 variant are supposed to be more susceptible to metal toxicity, including MeHg known to be neurotoxic especially early in life. The purpose of present work was to estimate relations between ApoE polymorphisms and concentrations of selected metal(loid)s (Hg, MeHg, As and Se) in mothers and their newborns, chronically exposed to low or moderate amounts of Hg, mostly through fish consumption during pregnancy.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA