Naslov
A single nucleotide polymorphism in the GLCCI1 gene is associated with response to asthma treatment in children

Autori
Banić, Ivana ; Rijavec, Matija ; Plavec, Davor ; Korosec, Peter ; Turkalj, Mirjana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
Pediatric Allergy and Asthma Meeting

Mjesto i datum
Berlin, Njemačka, 15.10.2015. - 17.10.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Asthma, children, Inhaled corticosteroids

Sažetak
Introduction: Inhaled corticosteroids (ICS) are the most widely prescribed medications for controlling asthma. Levels of endogenous glucocorticoids are heritable and vary significantly, both at baseline and in response to environmental perturbation. The level of response to treatment with ICS is characterized by high intra-individual repeatability and high inter- individual variability. Polymorphisms in GLCCI1, a gene important for the biological action of corticosteroids, could be associated with treatment response in asthmatics. Aims and Objectives: To determine treatment outcomes in children with asthma in association with GLCCI1 (rs37973) genotype. Methods: We recruited 252 children with asthma and clinically assessed their health status and treatment outcome over the period of 12 months at 3 time points: at recruitment point, after 6 months and after 1 year. Genetic material was extracted from whole blood samples and then genotyped for the rs37973 polymorphism in the GLCCI1 gene. Results: 210 children were treated with ICS continuously for at least 12 months. When treatment success was assessed by changes in asthma control according to GINA guidelines (changes in lung function, symptom occurrence, need for bronchodilatators) after 6 months of regular ICS use, the frequency of AA genotype was significantly higher in good responders compared to the GG genotype. This genotype related response was even more evident when comparing patients with moderate and bad response to treatment with good responders: the frequency of AA genotype was also significantly higher in good responders versus moderate and bad (inadequate) responders. The levels of response to treatment were defined as relative changes in asthma control (according to GINA) between clinical visits at 3 time points. Conclusions: Our results showed that adequate (good) levels of response to treatment with ICS in children with asthma, assessed as changes in asthma control parameters after 6 months of ICS use, are associated with a polymorphism in the GLCCI1 gene.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA