Naslov
Hepatitis C Treatment: A Review and Update.

Autori
Jakab, Jelena ; Žulj, Marinko ; Volarić, Nikola ; Tepeš, Bojan ; Včev, Aleksandar

Izvornik
Southeastern European medical journal (2459-9484) 1 (2017), 1; 11-18

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
hepatitis C infection ; treatment ; direct-acting antivirals

Sažetak
Hepatitis C virus infection (HCV) infects approximately 185 million individuals worldwide. It is a leading cause of chronic liver disease and the primary reason for liver transplantation. The main aim of antiviral treatment is to achieve a sustained virologic response, which means eradication of the virus. The combination of pegylated-interferon and ribavirin was the standard of care for over a decade, despite the long treatment duration and severe adverse effects. The introduction of direct-acting antivirals with pan-genomic properties and excellent tolerance increased rates of SVR and shortened the duration of the therapy. Furthermore, it allowed clinicians to customise HCV therapy according to important clinical parameters such as HCV- genotype and liver fibrosis stage.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA