Naslov
Proton magnetic resonance spectroscopy in Huntington's disease accompanying neuroborreliosis

Autori
Šarac, Helena ; Ozretić, David ; Henigsberg, Neven ; Hrabac, Pero ; Bagarić, Ivan ; Bagarić-Krakan, Lucija

Izvornik
Psychiatria Danubina (0353-5053) 29 (2017), 2; 226-230

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
MRS ; Huntington's disease ; neuroborreliosis

Sažetak
Pathophysiology of HD is still unclear, and potential HD biomarkers are lacking. Discrepant findings have been reported in the literature about the role of the proton magnetic resonance spectroscopy (MRS) as an biomarker of the Huntington's disease (HD) and neuroborreliosis. Recently, the autors of the largest longitudinal study reported putaminal MRS measurements of myo-inositol (mI) and N-acetylaspartate (NAA) as a potential biomarkers of HD onset and progression (Sturrock et al. 2010). Only one report demonstrated MRS abnormalities in patients with neuroborreliosis (Ustymovicz et al. 2004). Herein, we quantified metabolic abnormalities by using proton MRS and assesed the extent of structural abnormalities in brain MRI in three HD gene carriers ; one patient with HD and neuroborreliosis, one adult-onset HD patient and one presymnptomatic HD (pre-HD) individual.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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