Naslov
The thyroid dysfunction influence on the risk factors of cardiovascular diseases

Autori
Lukić, Maja ; Mandić, Sanja ; Jonjić, Jasna ; Horvat, Vesna ; Debeljak, Željko ; Lukić, Iva ; Šerić, Vatroslav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Clinical Chemistry and Laboratory Medicine / - , 2016, EA288-eA288

Skup
The 4th Joint EFLM-UEMS Congress “Laboratory Medicine at the Clinical Interface” Warsaw, Poland

Mjesto i datum
Varšava, Poljska, 21.09.2016. - 24.09.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
hypothyroidism, cardiovascular diseases, lipid profile, inflammatory markers

Sažetak
Subclinical hypothyroidism (SCH) is a common endocrine disorder characterized by elevated TSH values with normal FT4 and FT3. There is evidence that hypothyroidism is associated with abnormal lipid metabolism, while available data for SCH is rather contradictory. The aim of our study was to assess the relationship between SCH, the lipid profile and inflammatory markers as potential risk factors of cardiovascular diseases, as well as the presence of thyroid antibodies. Our study included 29 female patients with SCH and 31 female control patients, all aged similarly. TSH, FT4, FT3, anti-TPO and anti-Tg were determined by chemiluminescent immunoassay using UniCel_Dxl600. Analysis of total cholesterol, trigylcerides, HDL-cholesterol, LDLcholesterol, apoA1, apoB and CRP was performed by means of Beckman_CoulterAU480, using reagents from the same manufacturer. CRP, apoA1 and apoB were determined by immunoturbidimetry, while the others were analyzed using enzymatic spectrophotometry tests. Statistical analysis was performed using MedCalc. T-test analysis yielded statistically significantly higher values of total cholesterol (p = 0, 010), LDL- cholesterol (p = 0, 008) and apo B lipoprotein (p = 0, 008) in patients with SCH. Neither of the tests included in the study correlated with TSH values. Fischer exact test yielded a significantly wider presence of positive anti- TPO in patients with SCH (p = 0, 001). Our results show that abnormal lipid status can be found in patients with SCH. Therefore, a more profound laboratory diagnostics should be performed in order to prevent potential complications associated with CVD. Moreover, the common presence of thyroid antibodies in these patients suggests a higher susceptibility for development of clinical hypothroidism.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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