Pregled bibliografske jedinice broj: 887038
NDE1 and NDEL1: Multimerisation, alternate splicing and DISC1 interaction
NDE1 and NDEL1: Multimerisation, alternate splicing and DISC1 interaction // Neuroscience letters, 449 (2009), 3; 228-233 doi:10.1016/j.neulet.2008.10.095 (međunarodna recenzija, članak, znanstveni)
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Naslov
NDE1 and NDEL1: Multimerisation, alternate splicing and DISC1 interaction
Autori
Bradshaw, Nicholas J. ; Christie, Sheila ; Soares, Dinesh C. ; Carlyle, Becky C. ; Porteous, David J. ; Millar, J. Kirsty
Izvornik
Neuroscience letters (0304-3940) 449
(2009), 3;
228-233
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
DISC1 ; LIS1 ; NDE1 ; NDEL1 ; Schizophrenia
Sažetak
Nuclear Distribution Factor E Homolog 1 (NDE1) and NDE-Like 1 (NDEL1) are highly homologous mammalian proteins. However, whereas NDEL1 is well studied, there is remarkably little known about NDE1. We demonstrate the presence of multiple isoforms of both NDE1 and NDEL1 in the brain, showing that NDE1 binds directly to multiple isoforms of Disrupted in Schizophrenia 1 (DISC1), and to itself. We also show that NDE1 can complex with NDEL1. Together these results predict a high degree of complexity of DISC1-mediated regulation of neuronal activity.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Temeljne medicinske znanosti, Biotehnologija
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE