Pregled bibliografske jedinice broj: 886679
Pathologic patterns of interleukin 10 expression – A review
Pathologic patterns of interleukin 10 expression – A review // Biochemia medica, 25 (2015), 1; 36-48 doi:10.11613/BM.2015.004 (međunarodna recenzija, pregledni rad, znanstveni)
CROSBI ID: 886679 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Pathologic patterns of interleukin 10 expression – A review
Autori
Trifunović, Jasenka ; Miller, Larisa ; Debeljak, Željko ; Horvat, Vesna
Izvornik
Biochemia medica (1330-0962) 25
(2015), 1;
36-48
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
autoimmune diseases ; inflammatory diseases ; interleukin 10 ; neoplasms ; polymorphisms, genetic
Sažetak
Interleukin 10 (IL-10) is important pleiotropic immunoregulatory cytokine which gene is located on chromosome 1 at 1q31-32. There are many genetic variants of IL-10 gene. However, the most studied are two dinucleotide repeats (microsatellites), IL10.G and IL10.R, located 1.2 kb and 4 kb upstream of the transcription start site and three single nucleotide polymorphisms (SNPs) -1082(G/A), -819(C/T) and -592(C/A). A large number of studies have shown that IL-10 gene polymorphisms are associated with different diseases and play an important role in pathophysiology and clinical course of these diseases. This review summarizes published literature knowledge about the association of IL-10 polymorphisms and expression patterns with asthma, systemic lupus erythematosus, psoriasis, inflammatory bowel disease, rheumatoid arthritis, tuberculosis and some neoplasms.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
Klinički bolnički centar Osijek
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
