Pregled bibliografske jedinice broj: 885599
Falsely elevated serum oestradiol due to exemestane therapy
Falsely elevated serum oestradiol due to exemestane therapy // Annals of clinical biochemistry, 54 (2017), 3; 402-405 doi:10.1177/0004563216674031 (podatak o recenziji nije dostupan, prikaz, znanstveni)
CROSBI ID: 885599 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Falsely elevated serum oestradiol due to exemestane
therapy
Autori
Mandić, Sanja ; Kratzsch, Jutrgen ; Mandić, Dario ; Debeljak, Željko ; Lukuć, Iva ; Horvat, Vesna ; Gaudl, Alexander ; Šerić, Vatroslav
Izvornik
Annals of clinical biochemistry (0004-5632) 54
(2017), 3;
402-405
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, prikaz, znanstveni
Ključne riječi
Immunoassay ; mass spectrometry ; steroid hormones
Sažetak
In this study, we present a case of falsely elevated oestradiol (E2) concentration, determined by two immunoassays, in a breast cancer patient receiving exemestane therapy. The positive bias of immunochemical measurements was revealed using liquid chromatography tandem mass spectrometry which showed undetectable E2 concentration. The discrepancy is expected to be a consequence of the structural resemblance of E2 and exemestane sharing the same steroidal backbone. Inaccurate laboratory findings in therapy monitoring, as in this case, may lead to unnecessary changes of therapy.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
Klinički bolnički centar Osijek,
Medicinski fakultet, Osijek
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
