Naslov
Phytochemical Aspects and Therapeutic Perspective of Cannabinoids in Cancer Treatment

Autori
Vladimir‐Knežević, Sanda ; Blažeković, Biljana ; Bival Štefan, Maja ; Kindl, Marija

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Natural Products and Cancer Drug Discovery

Urednik/ci
Badria, Farid A.

Izdavač
IntechOpen

Grad
Rijeka

Godina
2017

Raspon stranica
111-139

ISBN
978-953-51-3314-8

Ključne riječi
cannabinoids ; phytochemistry ; THC ; CBD ; cancer

Sažetak
Cannabinoids comprise the plant‐derived compounds and their synthetic derivatives as well as endogenously produced lipophilic mediators. Phytocannabinoids are terpenophenolic secondary metabolites predominantly produced in Cannabis sativa L. The principal active constituent is delta‐9‐ tetrahydrocannabinol (THC), which binds to endocannabinoid receptors to exert its pharmacological activity, including psychoactive effect. The other important molecule of current interest is non‐ psychotropic cannabidiol (CBD). Since 1970s, phytocannabinoids have been known for their palliative effects on some cancer‐associated symptoms such as nausea and vomiting reduction, appetite stimulation and pain relief. More recently, these molecules have gained special attention for their role in cancer cell proliferation and death. A large body of evidence suggests that cannabinoids affect multiple signalling pathways involved in the development of cancer, displaying an anti‐ proliferative, proapoptotic, anti‐angiogenic and anti‐metastatic activity on a wide range of cell lines and animal models of cancer. These findings have led to the development of clinical studies to investigate potential anti‐ cancer activity in humans, but reliable clinical evidence for this therapeutic option is still missing.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

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