Naslov
Minimal Helix in the Ferrocene Peptide

Autori
Nuskol, Marko ; Kodrin, Ivan ; Đaković, Marijana ; Šupljika, Filip ; Čakić Semenčić, Mojca

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Solid-State Science & Research - Book of Abstracts / Juribašić Kulcsár, Marina ; Halasz, Ivan - Zagreb, 2017

ISBN
978-953-7941-15-4

Skup
Solid-State Science & Research

Mjesto i datum
Zagreb, Hrvatska, 28.06.2017. - 30.06.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Ferrocene ; Peptide ; Conformational Analysis

Sažetak
We have recently demonstrated that introduction of minimal peptide sequence on aminoferrocene may induce the formation of a β-turn-like structures in solution as well as in the solid state of the derived Boc-(AA)2-NH-Fc peptides. As a continuation of the previous work, we have synthesized higher analogues of these bioconjugates with a potential to form minimum sized peptide helices. Herein, we present the extensive study of conformational preferences of Boc-D-Pro-L-Pro-L-Ala-NH-Fc using NMR-, IR- and CD-spectroscopy, X-ray diffraction and DFT calculations. Results obtained from various techniques indicate that dominant conformation of I is stabilized by two intramolecular hydrogen bonds and ordered in a helical manner in solution as well as in the solid state.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA