Naslov
The antioxidative activity of some quaternary quinuclidinium salts

Autori
Odžak, Renata ; Šprung, Matilda ; Soldo, Barbara ; Bazina, Linda ; Primožič Ines

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
18th Tetrahedron Symposium - New Developments in Organic Chemistry

Mjesto i datum
Budimpešta, Mađarska, 27.06.2017. - 30.06.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
quaternary salts, antioxidative activity, ORAC assay

Sažetak
Two series of quaternary ammonium salts were synthetized by quaternization of quinuclidine- 3-ol with a different benzyl or n-alkyl bromides. All compounds were obtained in very good yields after which they were further characterized by physical means and FTIR, 1H and 13C NMR spectroscopies. Given the previously determined role of quinuclidine as a chemical compound displaying a broad range of biological activities, we were interested how quaternization with different substituents would affect these properties. The antioxidative activities were evaluated by oxygen radical absorbance capacity (ORAC) assay and preliminary results suggest that substitution with benzyl or n-alkyl bromides at N position positively affects ORAC values. Among the tested samples, the compound with the longest alkyl chain displayed the highest ORAC value implicating a possible higher biological potential. Further evaluation of these results by DPPH method and determination of the cellular antioxidant capacity are currently underway.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA