Naslov
Lipoproteine A in normal pregnancy – A preliminary report from the CRIBS study

Autori
Zajc Petranović, Matea ; Havaš Auguštin, Dubravka ; Šarac, Jelena ; Novokmet, Natalija ; Pribačić Ambrožić, Vanda ; Perinić Lewis, Ana ; Klopotan, Ana ; Carić, Tonko ; Sindik, Joško ; Čoklo, Miran ; Lela, Ivana ; Vidović, Antonija ; Karelović, Deni ; Škrabić, Veselin ; Žižić, Ana ; Stanišić, Lada ; Orehovec, Biserka ; Romić, Željko ; Janković, Stipan ; Šelović, Alen ; Missoni, Saša

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Program and Abstracts / Primorac, Dragan ; Schanfield, Moses ; Vuk-Pavlović, Stanimir ; Kayser, Manfred ; Ordog, Tamas - Zagreb : International Society for Applied Biological Sciences (ISABS), 2017, 200-200

ISBN
978-953-57695-2-1

Skup
10th ISABS Conference on Forensic and Anthropologic Genetics and Mayo Clinic Lectures in Individualized Medicine

Mjesto i datum
Dubrovnik, Hrvatska, 19.06.2017. - 23.06.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
CRIBS ; pregnancy ; newborns` anthropometry ; lipoprotein a ; biomarker

Sažetak
Concentration of lipoprotein (a), Lp(a), an important part of the clinical biomarker profile for atherosclerosis, in blood plasma varies both between and among populations. The elevated Lp(a) level in pregnancy were recognized as a risk factor for thrombosis and/or pre-eclampsia, but the referent values for uneventful pregnancies are yet undefined. The objective of this study was to test the association of fasting Lp(a) levels, taken between 22nd and 26th week of gestation, with possible predisposing factors (older age, smoking status, physical inactivity, hypertension, gestational diabetes), pregnancy outcomes (preterm birth, small/normal/large for gestational age) and newborns` anthropometric measures in 113 women (age range 19.8-41.7 yrs, mean 30.6±4.6 yrs) from the CRoatian Islands` Birth Cohort Study (CRIBS). In these women, with no history of chronic disease prior to pregnancy, Lp(a) leves varied largely, from 1.0 mg/dl to 127.3 mg/dl (median 13.1 mg/dl), but most of the women (88.5%) had Lp(a) <50 mg/dL, a cutoff which indicates moderate to high risk of CVD in general population. The results of multiple logistic regression analyses showed significance of older age (>35 yrs), smoking statuts (both current and ex-smokers) and hypertension in predicting Lp(a)≥50 mg/dL (p=0.017, Cox & Snell R2=0.162, Nagelkerke R2=0.333). Nor logistic, neither linear regression models used for the estimation of adjusted associations between Lp(a) and birth weight, length and head circumference, all z- standardized according to WHO, showed significant associations. In the CRIBS sample, elevated Lp(a) levels were not found to be a predictive biomarker for the pregnancy outcome and neonatal size.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Javno zdravstvo i zdravstvena zaštita, Etnologija i antropologija

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