Naslov
Antitumoral and antiviral activities of novel 1, 2, 3-triazolyl appended L-asorbic acid derivates

Autori
Meščić, Andrijana ; Harej, Anja ; Stepanić, Višnja ; Kraljević-Pavelić, Sandra ; Schols Dominique ; Raić Malić, Silvana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
10th Joint Meeting on Medicinal Chemistry, Book of Abstracts / Basarić, Nikola ; Namjesnik, Danijel ; Perković, Ivana ; Stepanić, Višnja - Zagreb : Hrvatsko kemijsko društvo, 2017, 174-174

ISBN
978-953-55232-8-4

Skup
The 10th Joint Meeting on Medicinal Chemistry 2017

Mjesto i datum
Srebreno, Hrvatska, 25.06.2017. - 28.06.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
L-ascorbic acid ; 1, 2, 3-triazole ; antitumoral ; antiviral ; antioxidant evaluation

Sažetak
L-Ascorbic acid is known as a ubiquitous carbohydrate of vital importance in living beings. Some pyrimidine and purine derivatives of 4, 5-didehydro-5, 6-dideoxy- and 6-deoxy-L- ascorbic acid exhibited selective and efficient cytostatic activities and displayed antiviral activities.[1] The 1, 2, 3-triazole moiety is extensively used in medicinal chemistry as a pharmacophore to modify known bioactive molecules and to potentiate their biological activities.[2, 3] Although click reactions are traditionally conducted in batch process, the progress toward increased sustainability that requires novel approaches with reduced environmental impact opened up in recent years continuous-flow as a novel alternative to conventional batch-based synthesis.[4] Realizing the benefits of flow chemistry as green and sustainable process and in continuation of our study towards the synthesis of 1, 2, 3-triazole-containing heterocycle pharmacophores, our aim was to improve the practical applicability of Cu(I)-catalyzed azide– alkyne 1, 3-dipolar cycloaddition (CuAAC) to provide diverse C-6-substituted 1, 2, 3-triazolyl 4, 5-unsaturated L-ascorbic acid derivatives using innovative enabling ultrasound and continuous flow hybrid system. Some compounds of presented series exhibit selective antiproliferative activities which will be demonstrated along with their antiviral potency

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA