Naslov
Komparativna patološka studija mamarnih tumora mačaka i pasa te imunohistokemijska ekspresija p53 i p63
(The comparative pathology study of feline and canine mammary tumors p53 and p63 immunohistochemical expression)

Autori
Faraguna, Siniša ; Vrkić Šola, Vanja ; Dekanić, Andrea ; Brezak, Renata ; Štifter, Sanja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
26th Ljudevit Jurak International Symposium on Comparative Pathology, Final programme & book of abstracts / - , 2017, 34-35

Skup
26th Ljudevit Jurak International Symposium on Comparative Pathology

Mjesto i datum
Zagreb, Hrvatska, 02.06.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
patologija ; imunohistokemija ; ekspresija ; pas ; mačka ; mliječna žlijezda
(pathology ; immunohistochemistry ; expression ; dog ; cat ; mammary gland)

Sažetak
Mammary tumors are common canine and feline neoplastic pathology. The prognosis varies significantly according to the tumor invasion degree. Since myoepithelial layer destruction is considered a differential diagnosis parameter of in situ from invasive lesions in human breast cancer we aimed to explore and evaluate the immunohistochemical expression of p63, a protein specifically expressed by myoepithelial cells of mammary gland. Furthermore its correlation with p53 expression was analyzed. The TP53 gene has the properties as a tumor suppressor gene and is the most frequently affected site of genetic alterations in human malignancies. It encodes the p53 protein in control of expression of a variety of genes involved in cell cycle regulation.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

POVEZANOST RADA