Pretraga

Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 881551

Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo.

Hirche, C.; Frenz, T.; Haas, S.F.; Döring, M.; Borst, K..; Tegtmeyer, .P.K; Brizić, Ilija; Jordan, S.; Keyser, K.; Chhatbar, C. et al.
Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo. // Cell Reports, 19 (2017), 2345-2356 doi:10.1016/j.celrep.2017.05.063 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 881551 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo.

Autori
Hirche, C. ; Frenz, T. ; Haas, S.F. ; Döring, M. ; Borst, K.. ; Tegtmeyer, .P.K ; Brizić, Ilija ; Jordan, S. ; Keyser, K. ; Chhatbar, C. ; Pronk, E. ; Lin, S. ; Messerle, M. ; Jonjić, Stipan ; Falk, C.S. ; Trumpp, A. ; Essers, M.A.G. ; Kalinke, U.

Izvornik
Cell Reports (2211-1247) 19 (2017); 2345-2356

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
long-term hematopoietic stem cell ; LT-HSC ; quiescence ; type I interferon ; IFN-I ; bone marrow ; virus infection ; vesicular stomatitis virus ; murine cytomegalovirus ; acute infection ; persistent infection ; bone marrow transplantation ; functional

Sažetak
Quiescent long-term hematopoietic stem cells (LTHSCs)are efficiently activated by type I interferon(IFN-I). However, this effect remains poorly investigatedin the context of IFN-I- inducing virus infections.Here we report that both vesicular stomatitis virus (VSV) and murine cytomegalovirus (MCMV) infection induce LT-HSC activation that substantially differs from the effects triggered upon injection of synthetic IFN-I-inducing agents. In both infections, inflammatory responses had to exceed local thresholds within the bone marrow to confer LT-HSC cell cycle entry, and IFN-I receptor triggering was not critical for this activation. After resolution of acute MCMV infection, LT-HSCs returned to phenotypic quiescence. However, non-acute MCMV infection induced a sustained inflammatory milieu within the bone marrow that was associated with long- lasting impairment of LT-HSC function. In conclusion, our results show that systemic virus infections fundamentally affect LT-HSCs and that also non-acute inflammatory stimuli in bone marrow donors can affect the reconstitution potential of bone marrow transplants.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Jonjić, Stipan, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Ilija Brizić (autor)

Avatar Url Stipan Jonjić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com doi.org www.cell.com

Citiraj ovu publikaciju:

Hirche, C.; Frenz, T.; Haas, S.F.; Döring, M.; Borst, K..; Tegtmeyer, .P.K; Brizić, Ilija; Jordan, S.; Keyser, K.; Chhatbar, C. et al.
Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo. // Cell Reports, 19 (2017), 2345-2356 doi:10.1016/j.celrep.2017.05.063 (međunarodna recenzija, članak, znanstveni)
Hirche, C., Frenz, T., Haas, S., Döring, M., Borst, K., Tegtmeyer, P., Brizić, I., Jordan, S., Keyser, K. & Chhatbar, C. (2017) Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo.. Cell Reports, 19, 2345-2356 doi:10.1016/j.celrep.2017.05.063.
@article{article, author = {Hirche, C. and Frenz, T. and Haas, S.F. and D\"{o}ring, M. and Borst, K.. and Tegtmeyer, .P.K and Brizi\'{c}, Ilija and Jordan, S. and Keyser, K. and Chhatbar, C. and Pronk, E. and Lin, S. and Messerle, M. and Jonji\'{c}, Stipan and Falk, C.S. and Trumpp, A. and Essers, M.A.G. and Kalinke, U.}, year = {2017}, pages = {2345-2356}, DOI = {10.1016/j.celrep.2017.05.063}, keywords = {long-term hematopoietic stem cell, LT-HSC, quiescence, type I interferon, IFN-I, bone marrow, virus infection, vesicular stomatitis virus, murine cytomegalovirus, acute infection, persistent infection, bone marrow transplantation, functional}, journal = {Cell Reports}, doi = {10.1016/j.celrep.2017.05.063}, volume = {19}, issn = {2211-1247}, title = {Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo.}, keyword = {long-term hematopoietic stem cell, LT-HSC, quiescence, type I interferon, IFN-I, bone marrow, virus infection, vesicular stomatitis virus, murine cytomegalovirus, acute infection, persistent infection, bone marrow transplantation, functional} }
@article{article, author = {Hirche, C. and Frenz, T. and Haas, S.F. and D\"{o}ring, M. and Borst, K.. and Tegtmeyer, .P.K and Brizi\'{c}, Ilija and Jordan, S. and Keyser, K. and Chhatbar, C. and Pronk, E. and Lin, S. and Messerle, M. and Jonji\'{c}, Stipan and Falk, C.S. and Trumpp, A. and Essers, M.A.G. and Kalinke, U.}, year = {2017}, pages = {2345-2356}, DOI = {10.1016/j.celrep.2017.05.063}, keywords = {long-term hematopoietic stem cell, LT-HSC, quiescence, type I interferon, IFN-I, bone marrow, virus infection, vesicular stomatitis virus, murine cytomegalovirus, acute infection, persistent infection, bone marrow transplantation, functional}, journal = {Cell Reports}, doi = {10.1016/j.celrep.2017.05.063}, volume = {19}, issn = {2211-1247}, title = {Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo.}, keyword = {long-term hematopoietic stem cell, LT-HSC, quiescence, type I interferon, IFN-I, bone marrow, virus infection, vesicular stomatitis virus, murine cytomegalovirus, acute infection, persistent infection, bone marrow transplantation, functional} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

Citati:

    Altmetrijski pokazatelji:


    Podijeli:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font
    CROSBI koristi kolačiće (cookies) kako bi poboljšao funkcionalnost stranice.