Naslov
Entrapment of peptidoglycans and adamantyltripeptides into liposomes

Autori
Frkanec, Ruža ; Tomašić, Jelka ; Vranešić, Branka ; Ljevaković, Đurđica ; Šporec, Vesna ; Halassy, Beata ; Krstanović, Marina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XVII. Hrvatski skup kemičara i kemijskih inženjera; Abstracts/Sažetci / Vicković, Ivan - : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI) ; Hrvatsko kemijsko drustvo, 2001

Skup
XVII. Hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Osijek, Hrvatska, 10.06.2001. - 13.06.2001

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Sažetak
In this work we examined the incorporation of the peptidoglycans and adamantyltripeptides into the liposomes with the aim to possibly increase and optimize their therapeutic efficacy. Our studies concern two groups of immunomodulators: a) peptidoglycan monomer (PGM, b-D-GlcNAc-(1®4)-MurNAc-L-Ala-D-isoGln-meso-A2pm(eNH2)-D-Ala-D-Ala) and its two semisynthetic derivatives, Boc-L-tyrosyl-peptidoglycan monomer and (adamant-1-yl)-acetyl peptidoglycan monomer; b) synthetic adamantyltripeptides comprising a part of peptidoglycan structure (D- and L-(adamant-2-yl)-Gly-L-Ala-D-isoGln). The large multilamellar negatively charged vesicles using egg lecithin were prepared. The liposome preparations were chromatographed on the Sephadex G-50 or centrifuged in ultracentrifuge. The entrapment of peptidoglycans and the stability of respective preparations were followed in two ways: by the use of 14C-labelled peptidoglycans or by HPLC. The influence of the chemical structure (lipophilic-hydrophilic) on the amount of entrapped material into liposomes will be shown.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA