Naslov
Ferrocene-containing mannosides as inhibitors of E. coli adhesion

Autori
Kovač, Veronika ; Moguš, Leo ; Petrović Peroković, Vesna ; Tomić, Srđanka, Barišić, Lidija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
25. hrvatski skup kemičara i kemijskih inženjera : Knjiga sažetaka / Đaković, Marijana ; Šantić, Ana - Zagreb : Hrvatsko kemijsko društvo, 2017, 137-137

ISBN
978-953-55232-7-7

Skup
25. hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Poreč, Hrvatska, 19.04.2017. - 22.04.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Ferrocene ; Mannoside ; Inhibitor ; Hemagglutination

Sažetak
Bacterial adhesion to host cell surfaces is the prerequisite for the initiation of the infectious diseases. Urinary tract infections are the prevalent inflammatory diseases mainly caused by uropathogenic E. coli (UPEC). E. coli adhesion to the bladder epithelium is mediated through recognition of the tissue-surface mannosylated proteins with bacterial lectin FimH. The inhibition of this recognition-dependent interaction has been recognized as a promising strategy for the development of an anti-adhesion therapy. The mannosides with either aryl- or elongated alkyl-functionalized aglycon portions have been shown to be potent inhibitors of FimH- mediated adhesion. Herein, we present the synthesis of new bioorganometallics 8 and 9 containing amide groups, butyl or pentyl spacer and phenylalanine as an extra aromatic unit. The biological actvity of new compounds against bacterial lectin FimH is tested with hemagglutination inhbition assay (HAI).

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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