Naslov
Prevalence of cardiometabolic risk factors in subfertile women with different polycystic ovary syndrome (PCOS) phenotypes in Croatia

Autori
Alebić, Miro Šimun ; Stojanović, Nataša

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Maturitas ; Volume 100 / - , 2017, 175-176

Skup
11th European Congress on Menopause and Andropause: Empowering a personalized approach to healthy ageing

Mjesto i datum
Amsterdam, Nizozemska, 22.05.2017. - 24.05.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
polycystic ovary ; metabolic risk factor ; prevalence ; insulin resistance

Sažetak
This cross-sectional study aimed to estimate the prevalence of cardiometabolic risk factors in ethnically homogeneous women with different PCOS phenotypes undergoing IVF treatment. The study included 157 controls, 135 asymptomatic women with polycystic ovarian morphology (PCOM) and 236 women diagnosed with PCOS and phenotyped according to the Rotterdam criteria. Anthropometric measurements, transvaginal ultrasound scan and blood sampling for biochemistry analyses were performed on the same day in a single clinical center. Metabolic profiles and prevalence of cardiometabolic risk factors such as obesity, dyslipidemia and insulin resistance assessed by clinical-setting specific threshold were compared among the groups. Women with PCOS A were younger, more insulin resistant and had higher body mass index and larger waist circumference than other women. PCOS C and PCOS D women were similar in metabolic profile. Likewise, there was no difference in metabolic profiles between controls and PCOM. No difference in lipid profile was found between different PCOS phenotypes. Women with PCOS A phenotype had higher prevalence of obesity, insulin resistance and hypertriglyceridemia than other PCOS phenotypes. The prevalence of insulin resistance and hypertriglyceridemia in PCOS D (30% and 23.9%) was found to be intermediate between that of PCOS C (24.5% and 18.4%) and PCOS A (47.3% and 27%). The high prevalence of hypercholesterolemia (around 50%) was common feature of all groups. In conclusion, in women with PCOS, the presence of oligomenorrhea was associated with higher prevalence of metabolic disturbances compared with the presence of hyperandrogenism in both lean and obese women with PCOS. Obesity was more prevalent in hyperandrogenic PCOS phenotypes than in non-hyperandrogenic PCOS and controls. In obese controls, asymptomatic PCOM and PCOS women, prevalence of cardiometabolic risk factors was much higher than in their lean counterparts.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA