Pregled bibliografske jedinice broj: 879274
Clinical and prognostic significance of anisocytosis measured as a red cell distribution width in patients with colorectal cancer
Clinical and prognostic significance of anisocytosis measured as a red cell distribution width in patients with colorectal cancer // Qjm-an international journal of medicine, 110 (2017), 6; 361-367 doi:10.1093/qjmed/hcw223 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 879274 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Clinical and prognostic significance of anisocytosis measured as a red cell distribution width in patients with colorectal cancer
Autori
Kust, Davor ; Lucijanić, Marko ; Urch, Kristina ; Šamija, Ivan ; Ćelap, Ivana ; Kruljac, Ivan ; Prpić, Marin ; Lucijanić, Ivica ; Mateša, Neven ; Bolanča, Ante
Izvornik
Qjm-an international journal of medicine (1460-2725) 110
(2017), 6;
361-367
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
anemia, cancer, colorectal cancer, iron deficiency anemia, preoperative care, surgical procedures, operative neoplasms, patient prognosis, prognostic marker, inflammatory response, anisocytosis, red blood cell distribution width determination, tumor cell invasion
Sažetak
Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide, and detection of new prognostic markers is mandatory for patients to receive optimal oncological treatment. The aim of the study was to assess clinical and prognostic value of red cell distribution width (RDW) in patients with CRC. RDW values in 90 patients with CRC undergoing surgery for primary disease were analyzed in pre- and postoperative setting, and correlated with clinical and hematological parameters. Both pre- and postoperative RDW measurements were found to be associated with features of iron deficiency anemia, inflammatory response to tumor, advanced age and depth of tumor invasion. Optimal cutoff points were calculated to be 14% for preoperative and 13.6% for postoperative RDW measurements. Elevations in both pre- and postoperative RDW values had significant effects on survival in univariate and multivariate analyses. Effects were found to be independent of tumor related features, stage of the disease, development of anemia and aberrant inflammatory response to tumor. RDW is an integrative parameter reflecting tumor specific features and shows significant association with overall survival in patients with CRC. This is especially important in patients with stage 2 disease where elevation in preoperative RDW values can contribute to recognition of higher risk patients.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
KBC "Sestre Milosrdnice",
Klinička bolnica "Dubrava",
Opća bolnica Karlovac
Profili:
Ivana Ćelap
(autor)
Marin Prpić
(autor)
Ivan Šamija
(autor)
Davor Kust
(autor)
Marko Lucijanic
(autor)
Ante Bolanča
(autor)
Ivica Lucijanić
(autor)
Neven Mateša
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- MEDLINE