Naslov
Ultrasmall iron oxide nanoparticles for positive contrast MR imaging: structural, colloidal and magnetic properties

Autori
Babić-Stojić, Branka ; Jokanović, V. ; Milivojević, D. ; Požek, M ; Jagličić, Z. ; Makovec, D. ; Jović Orsini, N. ; Marković, M. ; Arsikin, K. ; Paunović, V.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Third regional roundtable: Refractory, process industry, nanotechnologies and nanomedicine ROSOV PINN 2017 Programme and The Book of Abstracts / Jokanović, Vukoman - Beograd : Vinča Institute of Nuclear Sciences, Belgrade, Serbia // Serbian Society for Nanotechnologies and Nanomedicine // Serbian Society for Refractory and Process Industry, 2017, 87-87

ISBN
978-86-921143-0-4

Skup
Third regional roundtable: Refractory, process industry, nanotechnologies and nanomedicine ROSOV PINN 2017

Mjesto i datum
Beograd, Srbija, 01.06.2017. - 02.06.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
MRI contrasts, nanoparticles, magnetic properties

Sažetak
Ultrasmall crystalline iron oxide nanoparticles (USPIO NPs), with majority of the particles less than 3 nm in size dispersed in an organic fluid, were synthesized by polyol method. ZFCFC bifurcation and ac susceptibility peaks reveal that the nanoparticles are superparamagnetic with a blocking temperature T_B ~ 10 K. Considerably reduced measured magnetic field dependent magnetization at T > T_B, compared to the calculated dependence for noninteracting superparamagnetic NPs with a log-normal distribution of particle sizes, can be well described by modifying this distribution with field dependent average magnetic particle diameter. NMR relaxivity measurements on water diluted nanoparticle dispersions at magnetic field 1.5 T gave longitudinal and transverse relaxivity values r_1 = 0.028 mmol-1 s-1 and r_2 = 0.050 mmol-1 s-1 which resulted in the relaxivity ratio, r_2/r_1 = 1.8. The USPIO NPs dispersions have shown the properties of positive T_1 MRI contrast agents: increasing MR signal intensity in the T_1 -weighted image with increasing iron concentration in a wide concentration range. Cytotoxicity studies revealed that the USPIO NPs dispersions did not exert any significant cytotoxic activity on the B16 mouse melanoma cells at Fe concentrations of 1 mmol and below.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Kemija, Temeljne medicinske znanosti

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