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Pregled bibliografske jedinice broj: 878139

3-(2-deoxy-β-d-erythro- pentafuranosyl)pyrimido[1, 2-α]purin-10(3H)-one deoxyguanosine adducts of workers exposed to asbestos fibers

Bonassi, Stefano; Cellai, Filippo; Munnia, Armelle; Ugolini, Donatella; Cristaudo, Alfonso; Neri, Monica; Milić, Mirta; Bonotti, Alessandra; Giese, Roger W, Peluso, Marco EM
3-(2-deoxy-β-d-erythro- pentafuranosyl)pyrimido[1, 2-α]purin-10(3H)-one deoxyguanosine adducts of workers exposed to asbestos fibers // Toxicology letters, 270 (2017), 1-7 doi:10.1016/j.toxlet.2017.02.008 (međunarodna recenzija, članak, znanstveni)

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Naslov
3-(2-deoxy-β-d-erythro- pentafuranosyl)pyrimido[1, 2-α]purin-10(3H)-one deoxyguanosine adducts of workers exposed to asbestos fibers

Autori
Bonassi, Stefano ; Cellai, Filippo ; Munnia, Armelle ; Ugolini, Donatella ; Cristaudo, Alfonso ; Neri, Monica ; Milić, Mirta ; Bonotti, Alessandra ; Giese, Roger W, Peluso, Marco EM

Izvornik
Toxicology letters (0378-4274) 270 (2017); 1-7

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Asbestos ; Tobacco smoking ; Oxidative stress and lipid peroxidationn ; M1dG adducts

Sažetak
Asbestos is the commercial name for a group of silicate minerals naturally occurring in the environment and widely used in the industry. Asbestos exposure has been associated with pulmonary fibrosis, mesothelioma, and malignancies, which may appear after a period of latency of 20–40 years. Mechanisms involved in the carcinogenic effects of asbestos are still not fully elucidated, although the oxidative stress theory suggests that phagocytic cells produce large amounts of reactive oxygen species, due to their inability to digest asbestos fiber. We have conducted a mechanistic study to evaluate the association between 3-(2-deoxy-β-d-erythro- pentafuranosyl)pyrimido[1, 2-α]purin-10(3H)-one deoxyguanosine (M1dG) adducts, a biomarker of oxidative stress and lipid peroxidation, and asbestos exposure in the peripheral blood of 327 subjects living in Tuscany and Liguria, Italy, stratified by occupational exposure to asbestos. Adduct frequency was significantly greater into exposed subjects with respect to the controls. M1dG per 108 normal nucleotides were 4.0 ± 0.5 (SE) in 156 asbestos workers, employed in mechanic, naval, petrochemical, building industries, and in pottery and ceramic plants, versus a value of 2.3 ± 0.1 (SE) in 171 controls (p < 0.001). After stratification for occupational history, the effects persisted in 54 current asbestos workers, mainly employed in building renovation industry (2.9 ± 0.3 (SE)), and in 102 former asbestos workers (4.5 ± 0.7 (SE)), with p-values of 0.033, and <0.001, respectively. A significant effect of smoking on heavy smokers was found (p = 0.005). Our study gives additional support to the oxidative stress theory, where M1dG may reflect an additional potential mechanism of asbestos- induced toxicity.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA

Projekti:
INAIL
IARC

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb

Profili:

Avatar Url Mirta Milić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com doi.org

Citiraj ovu publikaciju:

Bonassi, Stefano; Cellai, Filippo; Munnia, Armelle; Ugolini, Donatella; Cristaudo, Alfonso; Neri, Monica; Milić, Mirta; Bonotti, Alessandra; Giese, Roger W, Peluso, Marco EM
3-(2-deoxy-β-d-erythro- pentafuranosyl)pyrimido[1, 2-α]purin-10(3H)-one deoxyguanosine adducts of workers exposed to asbestos fibers // Toxicology letters, 270 (2017), 1-7 doi:10.1016/j.toxlet.2017.02.008 (međunarodna recenzija, članak, znanstveni)
Bonassi, S., Cellai, F., Munnia, A., Ugolini, D., Cristaudo, A., Neri, M., Milić, M., Bonotti, A. & Giese, Roger W, Peluso, Marco EM (2017) 3-(2-deoxy-β-d-erythro- pentafuranosyl)pyrimido[1, 2-α]purin-10(3H)-one deoxyguanosine adducts of workers exposed to asbestos fibers. Toxicology letters, 270, 1-7 doi:10.1016/j.toxlet.2017.02.008.
@article{article, author = {Bonassi, Stefano and Cellai, Filippo and Munnia, Armelle and Ugolini, Donatella and Cristaudo, Alfonso and Neri, Monica and Mili\'{c}, Mirta and Bonotti, Alessandra}, year = {2017}, pages = {1-7}, DOI = {10.1016/j.toxlet.2017.02.008}, keywords = {Asbestos, Tobacco smoking, Oxidative stress and lipid peroxidationn, M1dG adducts}, journal = {Toxicology letters}, doi = {10.1016/j.toxlet.2017.02.008}, volume = {270}, issn = {0378-4274}, title = {3-(2-deoxy-β-d-erythro- pentafuranosyl)pyrimido[1, 2-α]purin-10(3H)-one deoxyguanosine adducts of workers exposed to asbestos fibers}, keyword = {Asbestos, Tobacco smoking, Oxidative stress and lipid peroxidationn, M1dG adducts} }
@article{article, author = {Bonassi, Stefano and Cellai, Filippo and Munnia, Armelle and Ugolini, Donatella and Cristaudo, Alfonso and Neri, Monica and Mili\'{c}, Mirta and Bonotti, Alessandra}, year = {2017}, pages = {1-7}, DOI = {10.1016/j.toxlet.2017.02.008}, keywords = {Asbestos, Tobacco smoking, Oxidative stress and lipid peroxidationn, M1dG adducts}, journal = {Toxicology letters}, doi = {10.1016/j.toxlet.2017.02.008}, volume = {270}, issn = {0378-4274}, title = {3-(2-deoxy-β-d-erythro- pentafuranosyl)pyrimido[1, 2-α]purin-10(3H)-one deoxyguanosine adducts of workers exposed to asbestos fibers}, keyword = {Asbestos, Tobacco smoking, Oxidative stress and lipid peroxidationn, M1dG adducts} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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