Pregled bibliografske jedinice broj: 876373
CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5+
CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5+ // Redox Biology, 12 (2017), 864-871 doi:10.1016/j.redox.2017.04.027 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 876373 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
CNS bioavailability and radiation protection of
normal hippocampal neurogenesis by a lipophilic Mn
porphyrin-based superoxide dismutase mimic,
MnTnBuOE-2-PyP5+
Autori
Leu, David ; Spasojević, Ivan ; Nguyen, Huy ; Denga, Brian ; Tovmasyan, Artak ; Weitner, Tin ; Sampaio, Romulo S. ; Batinić-Haberle, Ines ; Huang, Ting-Ting
Izvornik
Redox Biology (2213-2317) 12
(2017);
864-871
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Mn porphyrin ; bioavailability ; CNS ; radiation effects
Sažetak
Although radiation therapy can be effective against cancer, potential damage to normal tissues limits the amount that can be safely administered. In central nervous system (CNS), radiation damage to normal tissues is presented, in part, as suppressed hippocampal neurogenesis and impaired cognitive functions. Mn porphyrin (MnP)-based redox active drugs have demonstrated differential effects on cancer and normal tissues in experimental animals that lead to protection of normal tissues and radio- and chemo-sensitization of cancers. To test the efficacy of MnPs in CNS radioprotection, we first examined the tissue levels of three different MnPs – MnTE-2-PyP5+ (MnE), MnTnHex-2-PyP5+(MnHex), and MnTnBuOE-2- PyP5+(MnBuOE). Nanomolar concentrations of MnHex and MnBuOE were detected in various brain regions after daily subcutaneous administration, and MnBuOE was well tolerated at a daily dose of 3 mg/kg. Administration of MnBuOE for one week before cranial irradiation and continued for one week afterwards supported production and long-term survival of newborn neurons in the hippocampal dentate gyrus. MnP- driven S-glutathionylation in cortex and hippocampus showed differential responses to MnP administration and radiation in these two brain regions. A better understanding of how preserved hippocampal neurogenesis correlates with cognitive functions following cranial irradiation will be helpful in designing better MnP-based radioprotection strategies.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- EMBASE (Excerpta Medica)
