Pregled bibliografske jedinice broj: 873387
Molecular stratification of colorectal cancer
Molecular stratification of colorectal cancer // Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti, 522 (2015), 107-115 (podatak o recenziji nije dostupan, pregledni rad, znanstveni)
CROSBI ID: 873387 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Molecular stratification of colorectal cancer
Autori
Kapitanović, Sanja
Izvornik
Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti (1330-5301) 522
(2015);
107-115
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
colorectal cancer ; biomarkers ; molecular stratification
Sažetak
Colorectal cancer (CRC) is one of the most common cancers and one of the leading causes of cancer death in the Western world. The disease arises from the accumulation of mutations in oncogenes, tumor suppressor genes and mismatch repair genes during progression from normal colon epithelium to adenoma and metastatic carcinoma. Improved understanding of genetic events that underline tumor development and progression may contribute to new strategies for prevention, diagnosis as well as for therapy. The results of Human genome project showed that each person has its unique genetic “signature” as a consequence of a large number of inherited genetic variations. There are also sporadic molecular changes specific for each tumor type. This mini review will give some information about the most frequent molecular genetics changes in colorectal cancer and its molecular stratification due to its heredity, germline pharmacogenetic markers, somatic mutations and microsatellite instability.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti
