Naslov
Effect of atrazine on sperm parameters in rats

Autori
Šimić, Branimir ; Jakominić, Mihela ; Romac, Pavle ; Kniewald, Jasna

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Current Studies of Biotechnology - Volume II - Environment / Kniewald, Zlatko - Zagreb : Hrvatsko Društvo za Biotehnologiju, 2001, 195-202

Skup
Biotechnology and Environment 2001, Scientific Conference with International Participation

Mjesto i datum
Zagreb, Hrvatska, 19.02.2001. - 22.02.2001

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
atrazine; sperm count; sperm motility; testis; epididymis

Sažetak
Reduced sperm count and motility can be considered to be the markers of impaired spermatogenesis provoked by the influence of endocrine-active compounds in the environment. The purpose of this study was to evaluate the effects of s-triazine herbicide atrazine (2-chloro-4-ethylamino-6-isopropylamino-s-triazine) on male rat reproductive function by determining testicular sperm number, epididymal sperm number and motility. Animals were exposed i.p. to atrazine doses of 3, 7.5, 15, 30, 60 and 120 mg per kg body wt. twice a week over 60 days. At the end of atrazine exposure the testicular punctions showed a significant drop in sperm counts vs. control values (17% to 29%). Epididymal sperm number was lower in the animals exposed to doses of 3 and 7.5 mg of atrazine per kg body wt., but the decrease was not statistically significant. Significant differences were found in the groups of animals exposed to doses of 15 to 120 mg per kg body wt. in comparison with the control values. The drop in epididymal sperm number extended from about 36% to 77% as the dose increased. The dose-related changes in epididymal sperm motility were found in the same groups of animals. The motility decreased for about 52% to 97%. Presented results bring an additional insight into harmful effects of environmental chemicals such as pesticides on the reproductive process.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija

POVEZANOST RADA