Naslov
Synthesis, antioxidative and antiproliferative activity of methoxy amidino substituted benzamides and benzimidazoles

Autori
Cindrić, Maja ; Sović, Irena ; Martin-Kleiner, Irena ; Kralj, Marijeta ; Mašek, Tomislav ; Hranjec, Marijana ; Starčević, Kristina

Izvornik
Medicinal chemistry research (1054-2523) 26 (2017), 9; 2024-2037

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
amidines ; benzamides ; benzimidazoles ; methoxy groups ; antioxidative activity ; antiproliferative activity

Sažetak
Within this manuscript the synthesis and potential antioxidative and antiproliferative activity of novel methoxy amidino substituted bezamides 6-17 and benzimidazoles 23-28 and 32-35 is presented. Their antioxidative potency has been evaluated by in vitro spectrophotometric assays and preliminary structure-activity relationships among the synthesized compounds are discussed. The compound 28 bearing three methoxy groups on a phenyl ring and imidazolinyl amidine groupe on benzimidazole nucleous directly attached to the phenyl ring exhibited the most prominent reducing activity as well as free-radical scavenging activity. Furthermore all novel compounds were tested against three human cell lines: HCT 116 (colon carcinoma), H 460 (lung carcinoma) and MCF-7 (breast carcinoma). The most prominent antiproliferative effect in the single-digit micromolar range was observed for compound 33 on MCF-7 (IC50 = 9 µM) cell line, comparable to the standard etoposide.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Veterinarska medicina

POVEZANOST RADA