Mouse cytomegalovirus encoded immunoevasins and evolution of Ly49 receptors - sidekicks or enemies?

Železnjak, Jelena; Popović, Branka; Krmpotić, Astrid; Jonjić, Stipan; Lisnić Juranić, Vanda

doi:10.1016/j.imlet.2017.04.007

Pregled bibliografske jedinice broj: 870927

Mouse cytomegalovirus encoded immunoevasins and evolution of Ly49 receptors - sidekicks or enemies?

Železnjak, Jelena; Popović, Branka; Krmpotić, Astrid; Jonjić, Stipan; Lisnić Juranić, Vanda

Mouse cytomegalovirus encoded immunoevasins and evolution of Ly49 receptors - sidekicks or enemies? // Immunology letters, 189 (2017), 40-47 doi:10.1016/j.imlet.2017.04.007 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 870927 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Mouse cytomegalovirus encoded immunoevasins and evolution of Ly49 receptors - sidekicks or enemies?

Autori
Železnjak, Jelena ; Popović, Branka ; Krmpotić, Astrid ; Jonjić, Stipan ; Lisnić Juranić, Vanda

Izvornik
Immunology letters (0165-2478) 189 (2017); 40-47

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cytomegalovirus ; Immunoevasion ; Ly49 receptors ; MHC I ; Missing-self ; NK cells

Sažetak
Cytomegaloviruses (CMVs) have dedicated a large portion of their genome towards immune evasion targeting many aspects of the host immune system, particularly NK cells. However, the host managed to cope with the infection by developing multiple mechanisms to recognize viral threat and counterattack it, thus illustrating never-ending evolutionary interplay between CMV and its host. In this review, we will focus on several mechanisms of NK cell evasion by mouse CMV (MCMV), the role of host inhibitory and activating Ly49 receptors involved in the virus control and acquisition of adaptive features by NK cells as a consequence of MCMV infection

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Vanda Juranić Lisnić (autor)