Pretraga

Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 869473

1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro

Knežević Teofilović, Natalija; Bihi, Majjoub; Radić Stojković, Marijana; Tumir, Lidija; Ester, Katja; Kralj, Marijeta; Majhen, Dragomira; Oršolić, Nada; Lepur, Adriana; Vrbanec, Damir et al.
1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro // Bioorganic & medicinal chemistry letters, 27 (2017), 7; 1530-1537 doi:10.1016/j.bmcl.2017.02.048 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 869473 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro

Autori
Knežević Teofilović, Natalija ; Bihi, Majjoub ; Radić Stojković, Marijana ; Tumir, Lidija ; Ester, Katja ; Kralj, Marijeta ; Majhen, Dragomira ; Oršolić, Nada ; Lepur, Adriana ; Vrbanec, Damir ; Markotić, Alemka ; Dembić, Zlatko ; Weber, Alexander N.R ; Piantanida, Ivo ; Vugrek, Oliver ; Diken, Mustafa ; Knežević, Jelena

Izvornik
Bioorganic & medicinal chemistry letters (0960-894X) 27 (2017), 7; 1530-1537

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
phenantridines ; TLR ; PBMCs ; cytokines ; immunomodulation

Sažetak
We have previously demonstrated the nucleic acid binding capacity of phenanthridine derivatives (PHTs). Because nucleic acids are potent inducers of innate immune response through Toll-like receptors (TLRs), and because PTHs bear a structural resemblance to commonly used synthetic ligands for TLR7/8, we hypothesized that PHTs could modulate/activate immune response. We found that compound M199 induces secretion of IL-6, IL-8 and TNFα in human PBMCs and inhibits TLR3/9 activation in different cellular systems (PBMCs, HEK293 and THP-1 cell lines).

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
FP7-REGPOT-2012-2013-1

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb,
Klinika za infektivne bolesti "Dr Fran Mihaljević",
Klinički bolnički centar Zagreb

Profili:

Avatar Url Jelena Knežević (autor)

Avatar Url Oliver Vugrek (autor)

Avatar Url Zlatko Dembić (autor)

Avatar Url Damir Vrbanec (autor)

Avatar Url Marijana Radić Stojković (autor)

Avatar Url Dragomira Majhen (autor)

Avatar Url Marijeta Kralj (autor)

Avatar Url Katja Ester (autor)

Avatar Url Adriana Lepur (autor)

Avatar Url Nada Oršolić (autor)

Avatar Url Natalija Knežević (autor)

Avatar Url Lidija-Marija Tumir (autor)

Avatar Url Alemka Markotić (autor)

Avatar Url Ivo Piantanida (autor)

Poveznice na cjeloviti tekst rada:

doi doi.org www.sciencedirect.com

Citiraj ovu publikaciju:

Knežević Teofilović, Natalija; Bihi, Majjoub; Radić Stojković, Marijana; Tumir, Lidija; Ester, Katja; Kralj, Marijeta; Majhen, Dragomira; Oršolić, Nada; Lepur, Adriana; Vrbanec, Damir et al.
1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro // Bioorganic & medicinal chemistry letters, 27 (2017), 7; 1530-1537 doi:10.1016/j.bmcl.2017.02.048 (međunarodna recenzija, članak, znanstveni)
Knežević Teofilović, N., Bihi, M., Radić Stojković, M., Tumir, L., Ester, K., Kralj, M., Majhen, D., Oršolić, N., Lepur, A. & Vrbanec, D. (2017) 1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro. Bioorganic & medicinal chemistry letters, 27 (7), 1530-1537 doi:10.1016/j.bmcl.2017.02.048.
@article{article, author = {Kne\v{z}evi\'{c} Teofilovi\'{c}, Natalija and Bihi, Majjoub and Radi\'{c} Stojkovi\'{c}, Marijana and Tumir, Lidija and Ester, Katja and Kralj, Marijeta and Majhen, Dragomira and Or\v{s}oli\'{c}, Nada and Lepur, Adriana and Vrbanec, Damir and Markoti\'{c}, Alemka and Dembi\'{c}, Zlatko and Weber, Alexander N.R and Piantanida, Ivo and Vugrek, Oliver and Diken, Mustafa and Kne\v{z}evi\'{c}, Jelena}, year = {2017}, pages = {1530-1537}, DOI = {10.1016/j.bmcl.2017.02.048}, keywords = {phenantridines, TLR, PBMCs, cytokines, immunomodulation}, journal = {Bioorganic and medicinal chemistry letters}, doi = {10.1016/j.bmcl.2017.02.048}, volume = {27}, number = {7}, issn = {0960-894X}, title = {1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro}, keyword = {phenantridines, TLR, PBMCs, cytokines, immunomodulation} }
@article{article, author = {Kne\v{z}evi\'{c} Teofilovi\'{c}, Natalija and Bihi, Majjoub and Radi\'{c} Stojkovi\'{c}, Marijana and Tumir, Lidija and Ester, Katja and Kralj, Marijeta and Majhen, Dragomira and Or\v{s}oli\'{c}, Nada and Lepur, Adriana and Vrbanec, Damir and Markoti\'{c}, Alemka and Dembi\'{c}, Zlatko and Weber, Alexander N.R and Piantanida, Ivo and Vugrek, Oliver and Diken, Mustafa and Kne\v{z}evi\'{c}, Jelena}, year = {2017}, pages = {1530-1537}, DOI = {10.1016/j.bmcl.2017.02.048}, keywords = {phenantridines, TLR, PBMCs, cytokines, immunomodulation}, journal = {Bioorganic and medicinal chemistry letters}, doi = {10.1016/j.bmcl.2017.02.048}, volume = {27}, number = {7}, issn = {0960-894X}, title = {1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro}, keyword = {phenantridines, TLR, PBMCs, cytokines, immunomodulation} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

Citati:

    Altmetrijski pokazatelji:


    Podijeli:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font
    CROSBI koristi kolačiće (cookies) kako bi poboljšao funkcionalnost stranice.