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Pregled bibliografske jedinice broj: 867232

A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family

Aguilar, O.; Berry, R.; Rahim, M.; Reichel, J.; Popović, Branka; Tanaka, M.; Fu, Z.; Balaji, G.; Lau, T.; Tu, M. et al.
A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family // Cell, 169 (2017), 1; 58-71e14 doi:10.1016/j.cell.2017.03.002 (međunarodna recenzija, članak, znanstveni)

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Naslov
A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family

Autori
Aguilar, O. ; Berry, R. ; Rahim, M. ; Reichel, J. ; Popović, Branka ; Tanaka, M. ; Fu, Z. ; Balaji, G. ; Lau, T. ; Tu, M. ; Kirkham, C. ; Mahmoud, A. ; Mesci, A. ; Krmpotić, Astrid ; Allan, D. ; Makrigiannis, A. ; Jonjić, Stipan ; Rossjohn, J. ; Carlyle, J.

Izvornik
Cell (0092-8674) 169 (2017), 1; 58-71e14

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.

Sažetak
Natural killer (NK) cells play a key role in innate immunity by detecting alterations in self and non-self ligands via paired NK cell receptors (NKRs). Despite identification of numerous NKR- ligand interactions, physiological ligands for the prototypical NK1.1 orphan receptor remain elusive. Here, we identify a viral ligand for the inhibitory and activating NKRP1(NK1.1) receptors. This murine cytomegalovirus(MCMV)-encoded protein, m12, restrains NK cell effector function by directly engaging the inhibitory NKR-P1B receptor. However, m12 also interacts with the activating NKR-P1A/C receptors to counterbalance m12 decoy function. Structural analyses reveal that m12 sequesters a large NKR-P1 surface area via a ‘‘polar claw’’ mechanism. Polymorphisms in, and ablation of, the viral m12 protein and host NKR- P1B/C alleles impact NK cell responses in vivo. Thus, we identify the long-sought foreign ligand for this key immunoregulatory NKR family and reveal how it controls the evolutionary balance of immune recognition during host-pathogen interplay.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
MZOS-062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Jonjić, Stipan, MZOS ) ( CroRIS)
MZOS-062-0621261-1268 - Uloga imunosubverzivnih citomegalovirusnih gena u latenciji (Krmpotić, Astrid, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Stipan Jonjić (autor)

Avatar Url Astrid Krmpotić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com dx.doi.org

Citiraj ovu publikaciju:

Aguilar, O.; Berry, R.; Rahim, M.; Reichel, J.; Popović, Branka; Tanaka, M.; Fu, Z.; Balaji, G.; Lau, T.; Tu, M. et al.
A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family // Cell, 169 (2017), 1; 58-71e14 doi:10.1016/j.cell.2017.03.002 (međunarodna recenzija, članak, znanstveni)
Aguilar, O., Berry, R., Rahim, M., Reichel, J., Popović, B., Tanaka, M., Fu, Z., Balaji, G., Lau, T. & Tu, M. (2017) A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family. Cell, 169 (1), 58-71e14 doi:10.1016/j.cell.2017.03.002.
@article{article, author = {Aguilar, O. and Berry, R. and Rahim, M. and Reichel, J. and Popovi\'{c}, Branka and Tanaka, M. and Fu, Z. and Balaji, G. and Lau, T. and Tu, M. and Kirkham, C. and Mahmoud, A. and Mesci, A. and Krmpoti\'{c}, Astrid and Allan, D. and Makrigiannis, A. and Jonji\'{c}, Stipan and Rossjohn, J. and Carlyle, J.}, year = {2017}, pages = {58-71e14}, DOI = {10.1016/j.cell.2017.03.002}, keywords = {A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.}, journal = {Cell}, doi = {10.1016/j.cell.2017.03.002}, volume = {169}, number = {1}, issn = {0092-8674}, title = {A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family}, keyword = {A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.} }
@article{article, author = {Aguilar, O. and Berry, R. and Rahim, M. and Reichel, J. and Popovi\'{c}, Branka and Tanaka, M. and Fu, Z. and Balaji, G. and Lau, T. and Tu, M. and Kirkham, C. and Mahmoud, A. and Mesci, A. and Krmpoti\'{c}, Astrid and Allan, D. and Makrigiannis, A. and Jonji\'{c}, Stipan and Rossjohn, J. and Carlyle, J.}, year = {2017}, pages = {58-71e14}, DOI = {10.1016/j.cell.2017.03.002}, keywords = {A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.}, journal = {Cell}, doi = {10.1016/j.cell.2017.03.002}, volume = {169}, number = {1}, issn = {0092-8674}, title = {A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family}, keyword = {A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index

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