Naslov
I index is not an accurate indicator of icteria in conjugated hyperbilirubinemia
(II index is not an accurate indicator of icteria in conjugated hyperbilirubinemia)

Autori
Nikolac Gabaj, Nora ; Miler, Marijana ; Mihić, Roman

Izvornik
Clinica chimica acta (0009-8981) 473 (2017); 32-34

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Preanalytical phase ; Laboratory error ; Serum indices ; Interferences ; Icteria

Sažetak
Serum indices have become a standard in assessing degree of endogenous interferences in serum and plasma samples. The aim of this study was to evaluate accuracy of I index in comparison with total bilirubin concentration in icteric samples with ranging amount of conjugated bilirubin. This study retrospectively analyzed data from laboratory information system. Total, conjugated bilirubin and I index are measured on Abbott Architect c8000 (N=900). Agreement between total bilirubin and I index in subgroups according to proportion of direct bilirubin (< 50% and ≥50%) was investigated using Bland-Altman analysis. In samples where percentage of direct bilirubin accounts for< 50% of total bilirubin there was no statistically significant constant difference, while small proportional difference was observed (2.5%) between total bilirubin and I index. In samples where percentage of direct bilirubin accounts for ≥50% of total bilirubin, significant constant (26.6) and proportional difference (22.2%) were observed between total bilirubin and I index. I index is not accurate indicator of icteria if> 50% of bilirubin is conjugated. Manufacturers should declare icteria interference with both, bilirubin concentration and value of I index.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija

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