Naslov
Upregulation of the neuronal Per-Arnt-Sim domain protein 4 (Npas4) in the rat corticolimbic system following focal cerebral ischemia

Autori
Leong, Wai Khay ; Klarić, Thomas Stephen ; Lin, Yingxi ; Lewis, Martin David ; Koblar, Simon Andrea

Izvornik
European journal of neuroscience (0953-816X) 37 (2013), 11; 1875-1884

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
corticolimbic ; focal cerebral ischemia ; middle cerebral artery occlusion ; Npas4 ; rat brain

Sažetak
The neuronal Per-Arnt-Sim domain protein 4 (Npas4) is an important transcriptional regulator of synaptic plasticity and cognition. The present study characterises the in vivo neuroanatomical expression pattern of the Npas4 protein in a rat model of focal cerebral ischemia. Animals were subjected to unilateral middle cerebral artery occlusion for 2 h, after which the spatiotemporal and neuronal profiles of Npas4 protein expression were analysed by immunohistochemistry at different time points post-reperfusion. Focal cerebral ischemia induced an early, transient and robust upregulation of Npas4 in a brain region- dependent manner involving predominantly principal neurons. Interestingly, we observed a unique differential induction of Npas4 protein expression in corticolimbic regions of the rat brain that are critically linked to cognition and emotion. These findings suggest that stroke- induced Npas4 upregulation may be involved in a transcriptional regulatory program within the corticolimbic circuitry following an ischemic insult.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA