Naslov
Accelerated Achilles tendon healing with interleukin-1 receptor antagonist protein in rabbits

Autori
Pećin, Marko ; Kreszinger, Mario ; Vuković, Snježana ; Lipar, Marija ; Smolec, Ozren ; Radišić, Berislav ; Kos, Josip

Izvornik
Turkish journal of veterinary and animal sciences (1300-0128) 41 (2017), 1; 118-126

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Tendon healing ; Bonar scale ; Interleukin-1 ; Inflammation ; Rabbit
(tendon healing ; bonar scale ; interleukin-1 ; inflammation ; rabbit)

Sažetak
E current study describes the use of interleukin-1 receptor antagonist protein (IL-1Ra) as a possible strategy for optimizing tendon healing and repair by presenting histologically visible changes in rabbit Achilles tendon tissue a er longitudinal tenotomy. e study was carried out on 26 Californian rabbits divided into two equal groups. One was the experimental IRAP (interleukin-1 receptor antagonist) group and the second one was the PBS (puri ed bu ered saline) group. e PBS group was the control group. A er longitudinal tenotomy in both groups of rabbits, in the IRAP group IL-1Ra was applied locally, whereas PBS was applied in the control group. IL-1 concentration in Achilles tendon tissue was measured with an ELISA IL-1 rabbit kit. Local application of IL-1Ra resulted in 2.5-fold lower IL- 1 tissue concentration and prevented cytokine cascade activation and its proin ammatory e ects. Consequently, it prevented chronic tendon in ammation and improved Achilles tendon healing in rabbits. Histological changes in tendon tissue samples were evaluated by Bonar scale score with statistically signi cant di erences between groups (P ≤ 0.01).

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

POVEZANOST RADA