Naslov
Crystal Structure Study Of The Novel Purine Derivatives Of The 1-Aminocyclopropane-1- Carboxylic Acid

Autori
Cetina, Mario ; Nagl, Ante ; Hergold-Brundić, Antonija ; Mrvoš-Sermek, Draginja ; Džolić, Zoran ; Mintas, Mladen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
11th Slovenian-Croatian Crystallographic Meeting : Book of abstracts, programme / Golobič, A. ; Leban, Ivan ; Meden, A. - Ljubljana : Laboratory of Inorganic Chemistry, Faculty of Chemistry and Chemical Technology, 2002, 30-30

Skup
11th Slovenian-Croatian Crystallographic Meeting

Mjesto i datum
Bohinj, Slovenija, 27.06.2002. - 30.06.2002

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
crystal structure ; novel purine derivatives

Sažetak
Cyclopropane nucleoside analogues have been shown as potential antiviral and antitumor agents, as it was also known that strained three-membered ring are involved in many enzymatic processes. Therefore were prepared by multistep synthetic procedure the novel purine derivatives of 1-aminocyclopropane-1-carboxylic acid: (Z)-methyl 1-(N-tert- butoxycarbonyl)amino-2-(6-aminopurine-9- yl)cyclopropanecarboxylate ethanol solvate (1) and (Z)-methyl 1-(N-tert-butoxycarbonyl)amino- 2-[6-(N-pyrrolyl)purine-9- yl]cyclopropanecarboxylate (2). The single crystals of the compounds 1 and 2 were obtained by slow evaporation at room temperature from ethanol and methanol solution, respectively. The crystal data were collected using Philips PW1100/Stoe&Cie diffractometer using MoK radiation. The crystal structures were solved using direct methods. The oxygen atom O1 in the compound 1 was observed as disorder and it is represented in the Figure as O1a in the position of higher occupancy factor (74 %). 1 2 In the crystal structure of the compound 1 were observed four weak intermolecular hydrogen bonds: O5• • • N7, N16• • • N3, N6• • • O5 and N6• • • N1 ranging from 2.926(6) to 3.120(4) Å ; forming three-dimensional network, while the molecules in the crystal structure of the compound 2 are linked with one weak intermolecular hydrogen bond N16• • • N3 (3.018(4) Å ; ).

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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