Naslov
The Novel Spacered Cyclopropyl Nucleoside Analogues : Synthesis, Structural Studies And Biological Evaluation Of The Purine Supstituted 1-Aminocyclopropane-1-Carboxylic Acids And 1- Amino-1-Hydroxymethylcyclopropanes

Autori
Džolić, Zoran ; Kristafor, Vedran ; Cetina, Mario ; Nagl, Ante ; Hergold-Brundić, Antonija ; Mrvoš-Sermek, Draginja ; Slade, Neda ; Pavelić, Krešimir ; Balzarini, Jan ; De Clercq, Erik ; Mintas, Mladen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XV International Round Table "Nucleosides, Nucleotides & Nucleic Acids" / De Clercq, Erik, Herdewijn, Piet - Leuven, 2002, P-22

Skup
XV International Round Table "Nucleosides, Nucleotides & Nucleic Acids"

Mjesto i datum
Leuven, Belgija, 10.09.2002. - 14.09.2002

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
purine derivatives

Sažetak
The novel purine derivatives of 1- aminocyclopropane-1-carboxylic acid (7, 8) and 1-amino-1-hydroxymethylcyclopropane (11, 12) containing methylene spacer between the base and the cyclopropane ring were prepared by multistep synthetic route involving alkylation of appropriately substituted purine with specifically protected methyl 1-[N-(tert- Boc)amino]-2-(O-Ts-hydroxymethyl)cyclopropane- 1-carboxylate as a key reaction. Z- configuration of the novel compounds was determined by one and two dimensional 1H and 13C NMR techniques and X-ray structure analyses. The novel compounds were evaluated on cytostatic and antiviral activities on several cell lines. The compound 11 exhibited a more pronounced inhibitory activity against the proliferation of cervical carcinoma (HeLa) and human fibroblast (WI-38) cells than other types of tumor cell lines. None of the compounds showed inhibitory activities against CMV, VZV and several other viruses.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti

POVEZANOST RADA