Naslov
Fate and Effect of Engineered (Manufactured) Nanomaterials on Marine Ecosystem
(Fate and Effect of Engineered (Manufactured) Nanomaterials on Marine Ecosystem)

Autori
Jakšić, Željko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 5th Croatian Congress of Toxicology with International participation (CROTOX 2016), / Durgo, Ksenija - Zagreb : Institut za medicinska istraživanja i medicinu rada, 2016, 21-21

Skup
Croatian Congress of Toxicology with International participation (CROTOX 2016)

Mjesto i datum
Poreč, Hrvatska, 09.10.2016. - 12.10.2016

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
engineered (manufactured) nanomaterial ; marine nano(eco)toxicology, acute toxicology, mode of action, sub-lethal effects, physico-chemical processes, regulatory assessment

Sažetak
In the recent two decades the Engineered (Manufactured) Nanomaterials (ENMs) of widespread use become one of the marine contaminants of emerging concern. Their versatile physicochemical characteristics influence their fate and effect in marine ecosystem, and represent a novel challenges to the established suit of hazard assessment tests. The presentation will describe the pathways of ENMs in the marine ecosystem (water column and sediment), their fate and behaviour as well as interactions with macromolecules and living organisms. Special attention will be devoted to the physico-chemical processes of ENMs, like adsorption, dissolution, transformations and homo/hetero-aggregation in marine environment. The comprehensive state-of- the-art overview of marine nanotoxicology research (test systems and model organisms, uptake routes and mechanisms, body and/or intracellular trafficking/translocation/storage and bioaccumulation ; trophic transfer ; specific targets of effects, mode of actions and mechanisms of toxicity, sub-lethal effects and acute toxicity) will be outlined by case studies results presentation and ways forward discussed. The important processes such as immune response, oxidation stress and genotoxic effects will be explained and comment in details. Spatial emphasis will be given to question how environmental conditions determine exposure to and effect of ENMs. Furthermore, identification and avoidance of potential artefacts and misinterpretations in nano(eco)toxicity measurements will be pointed out. Finally, the lecture will provide an overview of the ENMs regulatory assessment (REACH, OECD) and future research needs/challenges (integration of ENMs chemistry, experimental modelling, high throughput screening, systems toxicology approach, realistic exposure and chronic effects/responses across different levels of biological organisations, effects on sediment species).

Izvorni jezik
Engleski

Znanstvena područja
Geologija, Kemija, Biotehnologija

POVEZANOST RADA