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Pregled bibliografske jedinice broj: 859430

Diagnostic value of a pattern of exhaled breath condensate biomarkers in asthmatic children

Maloča Vuljanko, Ivana; Turkalj, Mirjana; Nogalo, Boro; Bulat Lokas, Sandra; Plavec, Davor
Diagnostic value of a pattern of exhaled breath condensate biomarkers in asthmatic children // Allergologia et immunopathologia, 45 (2017), 1; 2-10 doi:10.1016/j.aller.2016.05.001 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 859430 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Diagnostic value of a pattern of exhaled breath condensate biomarkers in asthmatic children

Autori
Maloča Vuljanko, Ivana ; Turkalj, Mirjana ; Nogalo, Boro ; Bulat Lokas, Sandra ; Plavec, Davor

Izvornik
Allergologia et immunopathologia (0301-0546) 45 (2017), 1; 2-10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
asthma ; children ; diagnosis ; exhaled breath condrensate ; lung function test

Sažetak
Diagnosing asthma in children is a challenge and using a single biomarker from exhaled breath condensate (EBC) showed the lack of improvement in it. The aim of this study was to assess the diagnostic potential of a pattern of simple chemical biomarkers from EBC in diagnosing asthma in children in a real-life setting, its association with lung function and gastroesophageal reflux disease (GERD). In 75 consecutive children aged 5-7 years with asthma-like symptoms the following tests were performed: skin prick tests, spirometry, impulse oscillometry (IOS), exhaled NO (FENO), 24-hour oesophageal pH monitoring and EBC collection with subsequent analysis of pH, carbon dioxide tension, oxygen tension, and concentrations of magnesium, calcium, iron and urates. No significant differences were found for individual EBC biomarkers between asthmatics and non-asthmatics (p>0.05 for all). A pattern of six EBC biomarkers showed a statistically significant (p=0.046) predictive model for asthma (AUC=0.698, PPV=84.2%, NPV=38.9%). None to moderate association (R2 up to 0.43) between EBC biomarkers and lung function measures and FENO was found, with IOS parameters showing the best association with EBC biomarkers. A significantly higher EBC Fe was found in children with asthma and GERD compared to asthmatics without GERD (p=0.049). An approach that involves a pattern of EBC biomarkers had a better diagnostic accuracy for asthma in children in real-life settings compared to a single one. Poor to moderate association of EBC biomarkers with lung function suggests a complementary value of EBC analysis for asthma diagnosis in children.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Projekti:
277-0000000-3436 - Usporedba učinaka dva načina vođenja terapije astme u djece 12-18 godina (Plavec, Davor, MZOS ) ( CroRIS)
277-2770968-0963 - Rani pokazatelji razvoja alergijskih bolesti u djece (Turkalj, Mirjana, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Osijek,
Dječja bolnica Srebrnjak,
Fakultet za dentalnu medicinu i zdravstvo, Osijek

Profili:

Avatar Url Boro Nogalo (autor)

Avatar Url Mirjana Turkalj (autor)

Avatar Url Ivana Maloča Vuljanko (autor)

Avatar Url Sandra Bulat Lokas (autor)

Avatar Url Davor Plavec (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com doi.org

Citiraj ovu publikaciju:

Maloča Vuljanko, Ivana; Turkalj, Mirjana; Nogalo, Boro; Bulat Lokas, Sandra; Plavec, Davor
Diagnostic value of a pattern of exhaled breath condensate biomarkers in asthmatic children // Allergologia et immunopathologia, 45 (2017), 1; 2-10 doi:10.1016/j.aller.2016.05.001 (međunarodna recenzija, članak, znanstveni)
Maloča Vuljanko, I., Turkalj, M., Nogalo, B., Bulat Lokas, S. & Plavec, D. (2017) Diagnostic value of a pattern of exhaled breath condensate biomarkers in asthmatic children. Allergologia et immunopathologia, 45 (1), 2-10 doi:10.1016/j.aller.2016.05.001.
@article{article, author = {Malo\v{c}a Vuljanko, Ivana and Turkalj, Mirjana and Nogalo, Boro and Bulat Lokas, Sandra and Plavec, Davor}, year = {2017}, pages = {2-10}, DOI = {10.1016/j.aller.2016.05.001}, keywords = {asthma, children, diagnosis, exhaled breath condrensate, lung function test}, journal = {Allergologia et immunopathologia}, doi = {10.1016/j.aller.2016.05.001}, volume = {45}, number = {1}, issn = {0301-0546}, title = {Diagnostic value of a pattern of exhaled breath condensate biomarkers in asthmatic children}, keyword = {asthma, children, diagnosis, exhaled breath condrensate, lung function test} }
@article{article, author = {Malo\v{c}a Vuljanko, Ivana and Turkalj, Mirjana and Nogalo, Boro and Bulat Lokas, Sandra and Plavec, Davor}, year = {2017}, pages = {2-10}, DOI = {10.1016/j.aller.2016.05.001}, keywords = {asthma, children, diagnosis, exhaled breath condrensate, lung function test}, journal = {Allergologia et immunopathologia}, doi = {10.1016/j.aller.2016.05.001}, volume = {45}, number = {1}, issn = {0301-0546}, title = {Diagnostic value of a pattern of exhaled breath condensate biomarkers in asthmatic children}, keyword = {asthma, children, diagnosis, exhaled breath condrensate, lung function test} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

Uključenost u ostale bibliografske baze podataka::


  • Research4Life (Hinari)
  • ISI Web of Knowledge

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