Naslov
Synthesis and solution properties of PCL-b-PHPMA diblock copolymers containing stable nitroxyl radicals

Autori
Petrova, Svetlana ; Klepac, Damir ; Konefał, Rafał ; Kereïche, Sami ; Kováčik, Lubomír ; Filippov, Sergey K.

Izvornik
Macromolecules (0024-9297) 49 (2016), 15; 5407-5417

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
PCL-b-PHPMA ; Nitroxyl Radicals ; ESR/EPR ; DLS ; NMR

Sažetak
This work focuses on the synthesis and the aqueous solution properties of novel amphiphilic PCL-b-PHPMA diblock copolymers possessing 2, 2, 6, 6-tetramethylpiperidine-1-oxyl (TEMPO) stable radicals covalently conjugated to the hydrophobic poly(ε-caprolactone) (PCL) block. A new synthetic approach (a four-step pathway) combining ring-opening polymerization (ROP), carbodiimide chemistry (DCC method), a reversible addition–fragmentation chain transfer (RAFT) polymerization technique, and finally chemical oxidation was employed to successfully produce a series of TEMPO-containing PCL-b-PHPMA diblock copolymers for the first time. EPR spectroscopy was applied to verify successful oxidation of the synthesized diblock copolymers and to investigate the dynamics of the polymer chains before and after micellization. The diblock copolymers self-assembled in PBS solution into spherical radical-containing nanoparticles (RNPs), which were characterized by 1H NMR spectroscopy, dynamic (DLS), static (SLS) light scattering, and cryo-transmission electron microscopy (cryo-TEM). These novel RNPs could find applications, e.g., as drug delivery systems and for the treatment of oxidative stress injuries.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti

POVEZANOST RADA