Naslov
Impact of calcium ion on cytotoxic effect of the boroxine derivative, K2[B3O3F4OH]

Autori
Ivanković, Siniša ; Stojković, Ranko ; Maksimovic, Milka ; Galić, Borivoj ; Miloš, Mladen

Izvornik
Journal of enzyme inhibition and medicinal chemistry (1475-6366) 31 (2016), S3; 70-74

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Anticancer activity, boroxine, calcium ion, drug research

Sažetak
The effect of Ca2+ ions on the cytotoxic ability of boron heterocyclic compound dipotassium trioxohydroxytetrafluorotriborate(K2[B3O3F4OH]), on in vitro tumor cells (mammary adenocarcinoma 4T1, melanoma B16F10 and squamous cell carcinoma SCCVII) and non-tumoral fibroblast cells (mouse dermal L929 and hamster lung V79) was examined. At small concentrations of Ca2+ ions (0.42 mM), K2[B3O3F4OH] (3.85 mM) has a very strong cytotoxic effect on all cancer cells tested (89.1, 85.6 and 84.6%) and significantly less effect on normal cells (19.5 and 24.2%), respectively. Applying larger concentrations of Ca2+ ions (9.42– 72.42 mM), at the same concentration of K2[B3O3F4OH], no significant cytotoxic effect was detected on cancer cells and normal cells investigated. The selective ability of K2[B3O3F4OH], in the medium with a low concentration of Ca2+ ions has a strong cytotoxic effect on cancer cells and very weak effect in normal cells, opens up the possibility of its application in antitumor therapy.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti

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