Pregled bibliografske jedinice broj: 856157
Complex Genetics of Protein N-Glycosylation
Complex Genetics of Protein N-Glycosylation // Glycoscience: Biology and Medicine / • Endo, Tamao ; Seeberger, Peter H. ; Hart, Gerald W. ; Wong, Chi-Huey ; Taniguchi, Naoyuki (ur.).
Lahti: Springer, 2014. str. 1-7
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Naslov
Complex Genetics of Protein N-Glycosylation
Autori
Krištić, Jasminka ; Zoldoš, Vlatka ; Lauc, Gordan
Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni
Knjiga
Glycoscience: Biology and Medicine
Urednik/ci
• Endo, Tamao ; Seeberger, Peter H. ; Hart, Gerald W. ; Wong, Chi-Huey ; Taniguchi, Naoyuki
Izdavač
Springer
Grad
Lahti
Godina
2014
Raspon stranica
1-7
ISBN
978-4-431-54836-2
Ključne riječi
Glyco-genes, Genetic regulation, Epigenetics, N-glycosylation, Glycoproteins, Glycosyltransferases, Glycosidases, Nucleotide-activated sugars, Transporters
Sažetak
This chapter provides an overview of genetic regulation of glycosylation processes, with a focus especially on N-glycosylation of proteins. N-glycosylation is a highly abundant protein modification and N-glycans have numerous important structural, functional, and regulatory roles in various physiological processes. The number of genes involved in glycan synthesis is very large (>800) and, based on current knowledge, it is highly likely that this list of glyco-genes is still going to grow. Some of these glyco-genes encode proteins which are directly involved in glycan production (e.g., glycosyltransferases, glycosidases, nucleotide sugar transporters), while protein products of other glyco-genes participate in glycosylation mostly through regulatory interaction with key enzymes and other proteins that are directly involved in glycan assembly. Furthermore, accumulating evidences indicate that glycosylation processes are also affected by epigenetics.
Izvorni jezik
Engleski
