Pregled bibliografske jedinice broj: 85434
Effect of dietary calcium on cadmium absorption and retention in suckling rats
Effect of dietary calcium on cadmium absorption and retention in suckling rats // BioMetals, 15 (2002), 2; 175-182 doi:10.1023/A:1015212929481 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 85434 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Effect of dietary calcium on cadmium absorption and retention in suckling rats
Autori
Matek Sarić, Marijana ; Blanuša, Maja ; Piasek, Martina ; Varnai, Veda Marija ; Jureša, Dijana ; Kostial, Krista
Izvornik
BioMetals (0966-0844) 15
(2002), 2;
175-182
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
calcium supplementation ; cadmium ; suckling rat
Sažetak
The effect of calcium supplementation on absorption and retention of cadmium in the suckling period was evaluated in Wistar rat pups of both sexes. Animals were maintained in the litters with the mother rats and supplemented with 1%, 3% or 6% calcium (as CaHPO(4)x2H(2)O) in cow's milk by artificial feeding from day of birth 6 through 14. All rats were exposed to cadmium (as CdCl(2)xH(2)O) either orally or parenterally. Oral cadmium dose of 0.5 mg/kg body weight a day was administered through nine-day period of calcium supplementation and parenteral cadmium dose was injected subcutaneously in a single dose of 0.5 mg Cd/kg body weight prior to calcium supplementation. On experimental day 10 (at the age of pups of 15 days) all animals were killed and the liver, kidneys, brain and carcass (body without organs and skin) were removed for element analyses. Cadmium and essential elements calcium, zinc and iron were analysed in the tissues by atomic absorption spectrometry. Results showed that after oral exposure cadmium concentrations in all calcium-supplemented groups were significantly decreased in the organs and carcass and that the effect was dose-related. No such effect of calcium was found after parenteral cadmium exposure. Calcium supplementation per se significantly increased calcium concentration in the carcass and had no effect on iron in organs and zinc in carcass. It was concluded that calcium supplementation during the suckling period could be an efficient way of reducing oral cadmium absorption and retention without affecting tissue essential trace element concentrations. [References: 36]
Izvorni jezik
Engleski
Znanstvena područja
Javno zdravstvo i zdravstvena zaštita
POVEZANOST RADA
Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb
Profili:
Martina Piasek
(autor)
Dijana Jureša
(autor)
Marijana Matek Sarić
(autor)
Krista Kostial-Šimonović
(autor)
Veda Marija Varnai
(autor)
Maja Blanuša
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE