Naslov
Non-random genome distribution of translocations formed after exposure to gamma radiation: the need for standardization of the FISH method in biodosimetry
(Non-random genome distribution of translocations formed after exposure to gamma radiation:the need for standardization of the FISH method in biodosimetry)

Autori
Fučić, Aleksandra ; Lasan, Ružica ; Hitrec, Vlasta

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Contributed papers / - Ženeva : International Atomic Energy Agency (IAEA), 2002, 554-557

Skup
International Conference on Occupational Radiation Protection

Mjesto i datum
Ženeva, Švicarska, 26.08.2002. - 30.08.2002

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
biodosimetry; FISH; standardization

Sažetak
The study of chromosome translocations in relation with chromosome DNA-content after occupationla exposure to gamma radiation during non-destructive testing in industry. Eight subjects occupationally exposed to gamma radiation were analysed using fluorescent in situ hybridization (FISH) for chromosomes 1, 2 and 4. Distribution of translocations showed that chromosome 4 exhibited significantly the higher frequency of tranlsocations while chromosome 2 was significantly underrepresented respecting thier DNA content. Distribution of translocations in chromosome 1,2 and 4 are not in correlation with DNA content after occupational exposure to gamma radiation. Results of the study are in correlation with similar in vivo and in vitro studies. Non-random involvement of chromosomes point the necessity for standardization of chromosome sets in biodosimetry based on calculation of the genome equivalent

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA