Pregled bibliografske jedinice broj: 849822
Kinetic Features of Acetylcholinesterase Inhibitor <i>α</i>-terpinolene
Kinetic Features of Acetylcholinesterase Inhibitor α-terpinolene // Book of Abstracts, Special Issue of Bulletin of the Chemists and Technologists of Bosnia and Herzegovina / Korać, Fehim (ur.).
Sarajevo: Faculty of Science Sarajevo, 2016. str. 65-65 (poster, međunarodna recenzija, sažetak, ostalo)
CROSBI ID: 849822 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Kinetic Features of Acetylcholinesterase Inhibitor <i>α</i>-terpinolene
Autori
Vlajčević, Dina ; Radan, Mila ; Miloš, Mladen ; Burčul, Franko.
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo
Izvornik
Book of Abstracts, Special Issue of Bulletin of the Chemists and Technologists of Bosnia and Herzegovina
/ Korać, Fehim - Sarajevo : Faculty of Science Sarajevo, 2016, 65-65
Skup
2nd International Congress of Chemists and Chemical Engineers of Bosnia and Herzegovina
Mjesto i datum
Sarajevo, Bosna i Hercegovina, 21.10.2016. - 23.10.2016
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Alzheimer's disease ; acetylcholinesterase ; <i>α</i>-terpinolene ; kinetics ; inhibition
Sažetak
Alzheimer's disease (AD) is the most common form of dementia in modern society. It is estimated that there are less than 1% occurrence in population of people between 60 and 64 years old, while there is an exponential increase in older populations. Main symptoms of AD include disruption or loss of higher brain functions (i.e. memory, judgment, thought processes, speech and others). Inhibition of acetylcholinesterase (AchE) enzyme is crucial for ameliorating the symptoms in the first stages of AD and is the only pharmacotherapy to date. The aim of this paper was to test the inhibitory activity of <i>α</i>-terpinolene, naturally occurring monoterpene, on AChE and to determine the type and kinetic parameters of inhibition using various linear plots (i.e. Lineweaver-Burk, Eadie-Hofstee, Hanes- Woolf and Eisenthal – Cornish-Bowden). It was concluded that <i>α</i>-terpinolene exhibits mixed type of inhibition which was shown to be concentration dependent. Also, AChE inhibition kinetic parameters (i.e. K<sub>M</sub>, V<sub>max</sub>, K<sub>M</sub><sup>app</sup>, V<sub>max</sub><sup>app</sup>, K<sub>I</sub> and K<sup>'</sup><sub>I</sub>) were determined.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
HRZZ-IP-2014-09-6897 - Istraživanje bioaktivnih spojeva iz dalmatinskog bilja: njihov antioksidacijski karakter i utjecaj na enzimsku inhibiciju i zdravlje (BioActCom) (Miloš, Mladen, HRZZ - 2014-09) ( CroRIS)
Ustanove:
Kemijsko-tehnološki fakultet, Split
