Pregled bibliografske jedinice broj: 84751
Glucosinolates as possible revertants of drug-resistance
Glucosinolates as possible revertants of drug-resistance // Periodicum biologorum, 104 (2002), 4; 475-479 (međunarodna recenzija, članak, znanstveni)
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Naslov
Glucosinolates as possible revertants of drug-resistance
Autori
Durgo, Ksenija ; Osmak, Maja ; Garaj-Vrhovac, Vera ; Franekić Čolić, Jasna
Izvornik
Periodicum biologorum (0031-5362) 104
(2002), 4;
475-479
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
glucosinolates; HEp2 cells; drug-resistant CK2 subline; MTT asay; GSH
Sažetak
The major problem in cancer chemotherapy is the ability of tumor cellsto develop resistence to anticancer drugs. In attempent to overcome drug-resistance, various compounds have been tested. among them are plant compounds of Brassicaceae family. In the present study we examined the effect of cauliflower's extract and its active compoumd indole-3-carbinole on the two most important causes of drug-resistance: the activity of the P-glycoprotein and the lebel on intracellular glutathione (GSH). The experiments were done on the human parental laryngeal CK2 subline with increased activity of P-glycoprotein and increased level of GSH.
Izvorni jezik
Engleski
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
