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Pregled bibliografske jedinice broj: 846946

Prenatal mercury exposure, neurodevelopment and apolipoprotein E genetic polymorphism

Snoj Tratnik, Janja; Falnoga, Ingrid; Trdin, Ajda; Mazej, Darja; Fajon, Vesna; Miklavčič, Ana; Kobal, Alfred; Osredkar, Joško; Sešek Briški, Alenka; Krsnik, Mladen et al.
Prenatal mercury exposure, neurodevelopment and apolipoprotein E genetic polymorphism // Environmental research, 152 (2017), 375-385 doi:10.1016/j.envres.2016.08.035 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 846946 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Prenatal mercury exposure, neurodevelopment and apolipoprotein E genetic polymorphism

Autori
Snoj Tratnik, Janja ; Falnoga, Ingrid ; Trdin, Ajda ; Mazej, Darja ; Fajon, Vesna ; Miklavčič, Ana ; Kobal, Alfred ; Osredkar, Joško ; Sešek Briški, Alenka ; Krsnik, Mladen ; Neubauer, David ; Kodrič, Jana ; Stropnik, Staša ; Gosar, David ; Lešnik Musek, Petra ; Marc, Janja ; Jurkovič Mlakar, Simona ; Petrović, Oleg ; Vlašić- Cicvarić, Inge ; Prpić, Igor ; Milardović, Ana ; Radić Nišević, Jelena ; Vuković, Danijela ; Fišić, Elizabeta ; Špirić, Zdravko ; Horvat, Milena

Izvornik
Environmental research (0013-9351) 152 (2017); 375-385

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Mercury ; Selenium ; Lead ; Cord blood ; Neurodevelopment ; Apolipoprotein E ; Genetic polymorphism

Sažetak
The aim of the present study was to evaluate the association between prenatal exposure to mercury (Hg) and neurodevelopment of the child, taking into account genetic polymorphism of apolipoprotein E (Apoe) and other relevant confounders. Six hundred and one mother-child pairs were recruited from the central Slovenia region and 243 from Rijeka, on the Croatian coast of the northern Adriatic. The total Hg in cord blood, Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III) assessment at 18 months of age and Apoe genotyping was performed on 361 children ; 237 of them were from Slovenia and 124 from Croatia. The results showed negative association between low- to-moderate Hg exposure in children with normal neurodevelopmental outcome and cognitive and fine motor scores at 18 months of age as assessed by BayleyIII. The Hg-related decrease in cognitive score was observed only in children carrying atleastone Apoe ε4 allele, while the decrease in fine motor scores was independent of the Apoe genotype. Adjusting for selenium (Se) and lead (Pb) levels, a positive association between Se and the language score and a negative association between Pb and the motor score was observed, but not in the subgroup of children carrying the ε4 allele.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Kemijsko inženjerstvo, Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
273-0222882-2698 - Bioindikacija onečišćenja zraka u terestričkim ekosustavima

Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka,
OIKON d.o.o.

Profili:

Avatar Url Ana Milardović (autor)

Avatar Url Elizabeta Fišić (autor)

Avatar Url Igor Prpić (autor)

Avatar Url Inge Vlašić-Cicvarić (autor)

Avatar Url Jelena Radić Nišević (autor)

Avatar Url Zdravko Špirić (autor)

Avatar Url Oleg Petrović (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Snoj Tratnik, Janja; Falnoga, Ingrid; Trdin, Ajda; Mazej, Darja; Fajon, Vesna; Miklavčič, Ana; Kobal, Alfred; Osredkar, Joško; Sešek Briški, Alenka; Krsnik, Mladen et al.
Prenatal mercury exposure, neurodevelopment and apolipoprotein E genetic polymorphism // Environmental research, 152 (2017), 375-385 doi:10.1016/j.envres.2016.08.035 (međunarodna recenzija, članak, znanstveni)
Snoj Tratnik, J., Falnoga, I., Trdin, A., Mazej, D., Fajon, V., Miklavčič, A., Kobal, A., Osredkar, J., Sešek Briški, A. & Krsnik, M. (2017) Prenatal mercury exposure, neurodevelopment and apolipoprotein E genetic polymorphism. Environmental research, 152, 375-385 doi:10.1016/j.envres.2016.08.035.
@article{article, author = {Snoj Tratnik, Janja and Falnoga, Ingrid and Trdin, Ajda and Mazej, Darja and Fajon, Vesna and Miklav\v{c}i\v{c}, Ana and Kobal, Alfred and Osredkar, Jo\v{s}ko and Se\v{s}ek Bri\v{s}ki, Alenka and Krsnik, Mladen and Neubauer, David and Kodri\v{c}, Jana and Stropnik, Sta\v{s}a and Gosar, David and Le\v{s}nik Musek, Petra and Marc, Janja and Jurkovi\v{c} Mlakar, Simona and Petrovi\'{c}, Oleg and Vla\v{s}i\'{c}- Cicvari\'{c}, Inge and Prpi\'{c}, Igor and Milardovi\'{c}, Ana and Radi\'{c} Ni\v{s}evi\'{c}, Jelena and Vukovi\'{c}, Danijela and Fi\v{s}i\'{c}, Elizabeta and \v{S}piri\'{c}, Zdravko and Horvat, Milena}, year = {2017}, pages = {375-385}, DOI = {10.1016/j.envres.2016.08.035}, keywords = {Mercury, Selenium, Lead, Cord blood, Neurodevelopment, Apolipoprotein E, Genetic polymorphism}, journal = {Environmental research}, doi = {10.1016/j.envres.2016.08.035}, volume = {152}, issn = {0013-9351}, title = {Prenatal mercury exposure, neurodevelopment and apolipoprotein E genetic polymorphism}, keyword = {Mercury, Selenium, Lead, Cord blood, Neurodevelopment, Apolipoprotein E, Genetic polymorphism} }
@article{article, author = {Snoj Tratnik, Janja and Falnoga, Ingrid and Trdin, Ajda and Mazej, Darja and Fajon, Vesna and Miklav\v{c}i\v{c}, Ana and Kobal, Alfred and Osredkar, Jo\v{s}ko and Se\v{s}ek Bri\v{s}ki, Alenka and Krsnik, Mladen and Neubauer, David and Kodri\v{c}, Jana and Stropnik, Sta\v{s}a and Gosar, David and Le\v{s}nik Musek, Petra and Marc, Janja and Jurkovi\v{c} Mlakar, Simona and Petrovi\'{c}, Oleg and Vla\v{s}i\'{c}- Cicvari\'{c}, Inge and Prpi\'{c}, Igor and Milardovi\'{c}, Ana and Radi\'{c} Ni\v{s}evi\'{c}, Jelena and Vukovi\'{c}, Danijela and Fi\v{s}i\'{c}, Elizabeta and \v{S}piri\'{c}, Zdravko and Horvat, Milena}, year = {2017}, pages = {375-385}, DOI = {10.1016/j.envres.2016.08.035}, keywords = {Mercury, Selenium, Lead, Cord blood, Neurodevelopment, Apolipoprotein E, Genetic polymorphism}, journal = {Environmental research}, doi = {10.1016/j.envres.2016.08.035}, volume = {152}, issn = {0013-9351}, title = {Prenatal mercury exposure, neurodevelopment and apolipoprotein E genetic polymorphism}, keyword = {Mercury, Selenium, Lead, Cord blood, Neurodevelopment, Apolipoprotein E, Genetic polymorphism} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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