Naslov
Synthetic Proteins Designed Using Ternary Coding Patterns: From Nucleotide Information to Protein Structure, Function and Music

Autori
Štambuk, Nikola ; Konjevoda, Paško ; Manojlović, Zoran ; Štambuk, Albert ; Turčić, Petra ; Gotovac, Nikola

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Symmetry: Culture and Science / Symmetry and information in biological systems, including studies on the genetic code (Symmetry Festival 2016) / Darvas, György - Budimpešta : Symmetrion, 2016, 163-171

Skup
Symmetry Festival 2016 ; Information, Biology, Genetic Code

Mjesto i datum
Beč, Austrija, 18.06.2016. - 22.06.2016

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
synthetic ; protein ; genetic code ; information ; music

Sažetak
Binary and ternary coding patterns of the amino acid polarity play an important role in analysis and design of peptide and protein structures. Recent investigations made by different authors suggest that de novo proteins constructed using specific patterns of amino acid polarity could be used for different applications in science and nanotechnology. This paper presents a new rule-based system for the structural characterization and construction of de novo proteins, based on the ternary patterns of sequence polarity, i.e., polar amino acids (H, Q, N, K, D, E, R), neutral amino acids (S, P, T, W, G, Y), and nonpolar amino acids (F, L, I, M, V, A, C). The extracted rules may help to predict and design different supersecondary protein structures with high probability. Audification of the protein and gene sequences is discussed as a possible alternative/complementary method for the secondary and supersecondary structure analysis and design.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti

POVEZANOST RADA