Naslov
In vitro effect of zinc on superoxide anion production by polymorphonuclear leukocytes of diabetic patients

Autori
Gavella, Mirjana ; Lipovac, Vaskresenija ; Car, Antuanet

Izvornik
Acta Diabetologica (0940-5429) 37 (2000), 3; 135-137

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Polymorphonuclear leukocytes; superoxide anion; zinc diabetes

Sažetak
We evaluated the ability of zinc to modulsate the superoxide anion released by isolated, phorbol myristate acetate (PMA)-stimulated polymorphonuclear leukocytes (PMNs. In the presence of zinc at physiological level (20 micromol/l), a 40%-increase in superoxide anion production was detected. The direction (suppression or stimulation) of superoxide anion generation was dependent upon extracellular zinc level and did not discriminate type1 and 2 diabetic patients from normal controls. The mechanism(s) of dose-dependent pro-and antioxidative effects of zinc on isolated PMNs in vitro as well as the implication of this finding for the modulatory effect of Zn on PMN-superoxide anion production in vivo need further investigation.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA