Naslov
Phenyl isothiocyanate: Synthesis and biological potential

Autori
Blažević, Ivica ; Bilušić, Tea ; Generalić Mekinić, Ivana ; Burčul, Franko ; Čikeš-Čulić, Vedrana ; Stojanov, Diana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Special Issue of Bulletin of the Chemists and Technologists of Bosnia and Herzegovina / Topčagić, Anela ; Ostojić, Jelena - Sarajevo, 2016, 99-99

Skup
2nd International Congress of Chemists and Chemical Engineers of Bosnia and Herzegovina

Mjesto i datum
Sarajevo, Bosna i Hercegovina, 21.10.2016. - 23.10.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Phenyl isothiocyanate; Synthesis; Antioxidant activity; Anticancer activity; Cholinesterase inhibition; NMR

Sažetak
The sulfur-containing compounds, glucosinolates, a class of secondary metabolites are found in almost all plants of the order Capparales, in particular in the family Brassicaceae (e.g. broccoli and other cabbages). Glucotropaeolin, a glucosinolate associated with an uncommon endogenous glucohydrolase-myrosinase (E.C.3.2.1.147), operates like precursor to phenyl isothiocyanate. In order to investigate its biological properties the pure phenyl isothiocyanate was obtained by one-pot synthesis by reaction of aniline with CS2 in aqueous K2CO3 solutions affording the dithiocarbamate intermediate, which was further desulfurized with cyanuric acid at 0 °C to provide the corresponding phenyl isothiocyanate. The obtained compound was confirmed by GC-MS and spectroscopic techniques (FTIR, 1D and 2D NMR). Phenyl isothiocyanate was tested for its antioxidative (using FRAP, DPPH and Briggs-Rauscher methods), anticancer (using MTT method), and cholinesterase inhibitory activities (using Ellman method). These investigations confirmed this secondary metabolite to be a compound of primary interest.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Prehrambena tehnologija

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