Naslov
The Metabolites of Arachidonic Acid in Microvascular Function

Autori
Drenjančević, Ines ; Jukić, Ivana ; Mihaljević, Zrinka ; Ćosić, Anita ; Kibel, Aleksandar

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, pregledni

Knjiga
Microcirculation Revisited - From Molecules to Clinical Practice

Urednik/ci
Helena Lenasi

Izdavač
In Tech

Grad
Rijeka

Godina
2016

Raspon stranica
101-133

ISBN
978-953-51-2730-7

Ključne riječi
microcirculation, endothelium, arachidonic acid metabolites, 20‐HETE, EETs

Sažetak
Arachidonic acid (AA) metabolites have an important role in mediating vascular reactivity to various stimuli, affecting tissue perfusion and tissue supply. In addition, they exert proinflammatory or anti-inflammatory effects on vessels. AA is metabolized by cyclooxygenases (COX) 1 and 2 to prostaglandins (PGs) and thromboxane (TX), by lipooxygenase to leukotrienes ; by cytochrome P450 (CYP450)‐ hydroxylase to 20‐hydroxyeicosatetraenoic acid (20‐HETE) and by CYP450‐epoxygenase to epoxyeicosatrienoic acids (EETs). Increased vascular oxidative stress may induce non- enzymatic production of isoprostanes from AA, which, together with vasoconstrictor metabolites of AA underlie endothelial damage and impaired vascular function. The balance among vasodilator and vasoconstrictor metabolites of AA may be disturbed in cardiometabolic diseases. (e.g. hypertension, obesity, diabetes) Dietary habits significantly affect the metabolism of AA, particularly excessive kitchen salt (NaCl) intake. Control of environmental risks factors, good maintenance of the occurring diseases and balanced nutrition with restricted salt intake can significantly improve the metabolism of AA and alleviate microvascular dysfunction and subsequent organ damage. Current research on pharmacological manipulation of certain components of the AA pathways (such as 20‐HETE production inhibition or prolongation of the life of epoxyeicoatrienoic acids(EETs) by inhibitors of soluble epoxide hydrolaze (sEH)promises effective therapy of cardiovascular and cerebrovascular diseases in the future.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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