Naslov
Rosuvastatin reduces kidney malondialdehyde concentrations in rats

Autori
Rašić, Dubravka ; Vukšić, Antonija ; Peraica, Maja ; Lovrić, Jasna ; Bradamante, Vlasta

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Arhiv za higijenu rada i toksikologiju Supplement / Durgo, Ksenija - Zagreb : Institut za medicinska istraživanja i medicinu rada, 2016, 37-37

Skup
5th Croatian Congress of Toxicology with International Participation

Mjesto i datum
Poreč, Hrvatska, 09.10.2016. - 12.10.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Lipid peroxidation ; oxidative stress ; rats ; statins

Sažetak
Statins are drugs widely used to treat hypercholesterolemia and reduce the risk of cardiovascular morbidity and mortality in patients with coronary heart disease. The mechanism of their action may be the inhibition of oxidant formation and blocking the effects of reactive oxygen species (ROS). As reported in recent studies, rosuvastatin has a beneficial effect on the plasma lipid profile and can reduce serum cholesterol and ROS formation in diabetic patients. The aim of this work was to determine the influence of rosuvastatin on the prooxidant- antioxidant balance in rat kidneys. This study was performed on male normolipidemic Wistar rats (N=36) divided into two control (treated with saline 5 mg kg-1 per day) and two experimental rosuvastatin-treated (5 and 10 mg kg-1 per day) groups. Animals were treated orally for 21 days. Malondialdehyde (MDA) – parameter of lipid peroxidation was measured in the kidney tissue homogenate of control and treated animals using the method by Drury et al. (1997). Data were analysed using t-test. Results are expressed as Mean±STD. MDA concentration was significantly lower in both experimental groups compared to controls: 0.41±0.05 vs. 0.62±0.08 µmol g-1 tissue (5 mg kg-1 per day vs. control ; p<0.001) and 0.58±0.05 vs. 0.68±0.09 µmol g-1 tissue (10 mg kg- 1 per day vs. control ; p<0.05). Our results have shown that rosuvastatin possesses significant antioxidative effectiveness that is not dose- dependent. This antioxidative action extends beyond the lipid-lowering effects of statins.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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