Naslov
An estimation of urinary benzene, toluene, ethylbenzene, and isomeric xylenes cut-off values to distinguish nonsmokers and smokers in the general population

Autori
Brčić Karačonji, Irena ; Grba, Gala ; Brajenović Nataša ; Bulog, Aleksandar

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 5th Croatian Congress of Toxicology with International Participation CROTOX 2016 / Durgo, Ksenija - Zagreb : Hrvatsko toksikološko društvo, 2016, 59-59

Skup
5th Croatian Congress of Toxicology with international participation (CROTOX 2016)

Mjesto i datum
Poreč, Hrvatska, 09.09.2016. - 12.09.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
BTEX; human biomonitoring; SPME-GC/MS; urine

Sažetak
Volatile organic compounds benzene, toluene, ethylbenzene, o-, m-, and p-xylene (BTEX) are ubiquitous pollutants of the human environment since their main sources are vehicular exhausts and tobacco smoke. Due to the toxicological effects (carcinogenic, neurologic, immunologic, respiratory, etc.) of these airborne chemicals, exposure to low levels could also increase the health risk in the general population. The aim of this study was to estimate the urinary cut-off values to discriminate nonsmokers from smokers in the general population not occupationally exposed to BTEX. Nonsmokers (N=120 ; 65 females) aged 18-65 years (median 44 years) and smokers (N=120 ; 60 females) aged 20-63 years (median 43 years), smoking 16±9 cigarettes daily, were selected for the study. Urinary BTEX concentrations were measured by headspace solid phase microextraction (HS-SPME) followed by gas chromatography–mass spectrometry (GC-MS). The optimal urinary cut-off values for distinguishing current smokers from nonsmokers were 139 ng L-1 (95.0 % sensitivity, 80.0 % specificity) for benzene, 200 ng L-1 (80.8 % sensitivity, 85.0 % specificity) for toluene, 29 ng L-1 (90.8 % sensitivity, 50.0 % specificity) for ethylbenzene, 197 ng L-1 (67.5 % sensitivity, 74.2 % specificity) for m/p-xylene, and 86 ng L-1 (45.8 % sensitivity, 86.7 % specificity) for o-xylene. The data presented provides valuable information on the background exposure of the general population to BTEX and represents a baseline for future studies. Our results could provide guidelines for differentiating current smokers from nonsmokers in the Croatian population.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA